This technology is based on differential expression of key gene transcript variants (isoform - level gene expression) and was originally tested on a vast collection of
glioblastoma samples made available by the University of Pennsylvania.
The researchers also analyzed an independent database of 536
glioblastoma samples and found the same signature of eight genes in those cases.
Not exact matches
Biopsied
samples of
glioblastoma tumors contain high level of STK17A.
The team found that exposing
samples of human
glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.
From tissue and cell
samples from five
glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.
To test their hunch, the researchers isolated microvesicles from 30 frozen tumor
samples and looked for mRNA from a particular growth receptor unique to
glioblastomas.
«First we looked at pieces of the
glioblastoma genome from several
samples, and then we extended the analysis to a large set of
glioblastomas from the Cancer Genome Atlas project, sponsored by the National Cancer Institute.»