Sentences with phrase «glioblastoma stem»

The Transcription Factor ZFX Is Required for Maintaining the Tumorigenic Potential of Glioblastoma Stem Cells.

Nigericin and grisorixin methyl ester from the Algerian soil - living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition — Nassima Leulmi — Natural Product Research

Molecular Targeting of TRF2 Suppresses the Growth and Tumorigenesis of Glioblastoma Stem Cells.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

tumors from neural stem cells also contained more glioblastoma stem cells, cells that are believed to give rise to tumor recurrence after therapy,» says Lene Uhrbom, senior lecturer at the Department of Immunology, Genetics and Pathology and lead author of the study.

Zika virus has oncolytic activity against glioblastoma stem cells.

«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell article.

«Transcription factors distinguishing glioblastoma stem cells identified.»

Identifying the drivers of these different cellular states in glioblastoma stem cells could offer us the best opportunity for treating what remains an extremely difficult - to - treat tumor.»

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Not exact matches

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

The physician scientists sought to identify glioblastoma subtype - specific cancer stem cells.

Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothingGlioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothingglioblastomas but which, lacking tumor stem cells, were nothing of the kind.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

These findings provide further evidence of ONC201 as an inhibitor of cancer stem cells and support ongoing clinical trials in prostate cancer and glioblastoma that have shown evidence of tumor shrinkage.

«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.

«Our study suggests that if a cancer - causing mutation occurs in the neural stem cell population in the SVZ, it gives rise to the proneural or the neural glioblastoma subtype.

VIRUS VICTORY Zika virus (green) infects and kills stem cells (red) in human glioblastoma tissue, without infecting healthy brain cells.

In collaboration with co-senior authors Diamond and Milan G. Chheda, MD, of Washington University School of Medicine, and Jeremy N. Rich, MD, of UC San Diego, Zhu tested whether the virus could kill stem cells in glioblastomas removed from patients at diagnosis.

«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»

A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells.

Inhibition of the self - renewal in CD133 - positive glioblastoma TICs by PPAM was attributed to inhibition of stem cell regulatory pathways [67].

Analysis of glioblastoma tumor coverage by oncolytic virus - loaded neural stem cells using MRI - based tracking and histological reconstruction.

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

The findings may even have implications for studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells.

We initially focused on drilling down into the genetic differences between glioblastoma tumour stem cells and normal neural stem cells.

«These findings show that our cancer model will not only allow us to start understanding the biology of glioblastoma but will also allow us to answer many questions surrounding cancer stem cells,» says Verma.

His team is using innovative cell culture models to advance our understanding of brain stem cells and their potential role in glioblastoma.

The â $ œcancer stem cellâ $ hypothesis has invigorated the neuro - oncology field with a breath of fresh thinking that may end up shaking the foundation of old dogmas, such as the widely held belief that glioblastoma tumors are incurable because of infiltrative disease.

Frisco, TX About Blog Beloved and gentle husband, daddy, son, brother, friend, co-worker and neighbor who battled brain cancer - a glioblastoma in the brain stem that we call Spot.