Sentences with phrase «glioblastoma tumor»

Regulation of Glioblastoma Tumor - Propagating Cells by the Integrin Partner Tetraspanin CD151.

Analysis of glioblastoma tumor coverage by oncolytic virus - loaded neural stem cells using MRI - based tracking and histological reconstruction.

In the study, NYGC researchers and bioinformatics experts analyzed DNA and RNA from a glioblastoma tumor specimen and DNA from the patient's normal blood, and compared potentially actionable insights to those derived from a commercial targeted panel that had previously been performed.

A glioblastoma tumor requires large amounts of energy as it grows, and the dietary intervention works by drastically limiting the tumor's supply of glucose, Reynolds said.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

Now, a high - fat, low - carbohydrate version of the ketogenic diet has been shown to slow glioblastoma tumors by cutting back on the energy supply they need to thrive, said Brent Reynolds, Ph.D., a professor in the Lillian S. Wells Department of Neurosurgery.

Although researchers don't yet know exactly why it was effective, Reynolds said preliminary data show that the modified diet also appears to make glioblastoma tumors more sensitive to treatment with radiation and chemotherapy.

Biopsied samples of glioblastoma tumors contain high level of STK17A.

Shah and his team loaded the herpes virus into human MSCs and injected the cells into glioblastoma tumors developed in mice.

Neuroscientist Duane Mitchell of Duke University Medical Center and his colleagues confirmed in 2007 that CMV is active in at least 90 percent of glioblastoma tumors.

«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»

The study conducted at SciLifeLab shows that temozolomide itself not only is cytotoxically active against glioblastoma tumors but also against other types of brain tumors, such as medulloblastoma and metastases from other primary tumors.

The â $ œcancer stem cellâ $ hypothesis has invigorated the neuro - oncology field with a breath of fresh thinking that may end up shaking the foundation of old dogmas, such as the widely held belief that glioblastoma tumors are incurable because of infiltrative disease.

Not exact matches

Novocure's main focus to date has been treating glioblastoma, or GBM, a type of tumor that affects the brain.

Glioblastoma multiforme is the most common and deadliest of the glial tumors because the cells reproduce so rapidly.

In 2009 he had been diagnosed with a type of rapidly growing brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.

Glioblastoma remains one of the most difficult types of brain tumors to treat successfully.

Sen. John McCain of Arizona last week revealed he is battling glioblastoma, the most common and aggressive type of malignant brain tumor in adults.

The tumor is called a Glioblastoma multiforme: also called The Terminator.

Arizona Sen. John McCain, 80, was diagnosed with an aggressive brain tumor — glioblastoma — following an earlier craniotomy to remove a blood clot from above his left eye, the Mayo Clinic Hospital in Phoenix said.

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

The scientists also tested the therapy on tumors taken from two patients who had not responded to conventional therapy for their glioblastoma, a deadly form of brain cancer.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Although there have been great advances made in the treatment of leukemias and other cancers, little is known about how Glioblastomas are formed and how these tumors infiltrate the brain tissue.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

SapC - DOPS (saposin - C dioleoylphosphatidylserine), is a nanovesicle drug that has shown activity in glioblastoma, pancreatic cancer and other solid tumors in preclinical studies.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.

Glioblastoma is one of the most common types of malignant brain tumors in adults.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

Glioblastoma, the most common brain tumor in adults, has no effective long - term treatment and on average, patients live for 12 to 15 months after diagnosis, according to the National Cancer Institute.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

Identifying the drivers of these different cellular states in glioblastoma stem cells could offer us the best opportunity for treating what remains an extremely difficult - to - treat tumor.»

While there have been improvements in the current standard treatments, patients with glioblastoma (GBM), the most common and aggressive form of brain tumor, still suffer from a median survival rate of only 14.6 months and 5 - year overall survival rates of less than 10 %.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

And a small number of glioblastoma patients do not have CMV in their tumors.

In 2002 scientists showed that cytomegalovirus, or CMV, was active in the brain tumors but not the surrounding healthy tissue of all 27 patients they tested who had glioblastoma multiforme.

Baliga's group is also mapping networks in patients with glioblastoma, a particularly deadly type of brain tumor.

Glioblastoma accounts for about 15 percent of all brain tumors, is resistant to current therapies and has a survival as short as 15 months after diagnosis.

Looking through the microscope: The image illustrates the differences in tumor cells in glioblastoma patients.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

Glioblastomas are incurable malignant brain tumors.

Little is known, however, about the metabolic pathways that drive the growth of individual glioblastoma subtypes — knowledge that is crucial for developing novel and effective targeted therapies that might improve treatment for these lethal tumors.

«Though many challenges still remain, such work could potentially transform treatment outcomes for patients with glioblastoma and related brain tumors, for which current therapies provide limited benefits.»