Sentences with phrase «glioma stem»
Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem - Like Cells.
http://www.lerner.ccf.org/
Man J, Shoemake S, Zhou W, Fang X, Wu Q, Rizzo A, Prayson R, Bao S, Rich JN, Yu JS, Sema3C Promotes The Survival and Tumorigenicity of Glioma Stem Cells Through Rac1 Activation.
Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression.
The key to more effective treatment for glioma is to get to grips with the glioma stem cells, which share many characteristics with the normal neural stem cells in the brain.
«Inhibition of the EZH2 pathway slows growth of tumors in mouse brain derived from glioma stem cells from the enhancing margin of human tumors.
«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.
Dr. Sloan said, «The enhancing edge and the invading tumor are driven by glioma stem cells (GSCs) dependent on the EZH2 pathway.
«Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells.»
Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.
Nakano says UAB will be the only site in the Deep South for this unique trial aimed at a molecular target in glioma stem cells, a target that is different from the ones described in the Cancer Research paper.
Small numbers of glioma stem - like cells, or GSCs, drive the tumorigenicity of GBM and thus are prime targets for possible treatments.
«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.
They identified a subpopulation of glioma stem cells, which, unlike most glioma cells, did not accumulate substantial amounts of fluorescent product during photodynamic detection.
Mesenchymal glioma stem cells show significantly higher radiation resistance and high expression of DNA - repair genes;
Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.
«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.
«Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that inhibiting that enzyme might offer a promising therapeutic approach for high - grade gliomas that have a mesenchymal signature,» says principal investigator Ichiro Nakano, MD, PhD, associate professor of neurosurgery at the OSUCCC — James.
Not exact matches
For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.
In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancer.
A pilot study of vaccination with glioma antigen - peptides with Poly - ICLC for children with newly diagnosed malignant brain stem gliomas, non-brainstem high - grade gliomas, recurrent low - grade gliomas or recurrent high grade gliomas (NCT01130077).
A pilot study of vaccination with glioma antigen - peptides with Poly - ICLC for children with newly diagnosed malignant brain stem gliomas, non-brainstem high - grade gliomas, recurrent low - grade gliomas or recurrent high grade gliomas -LRB-
Of great interest, stem - like cells have also been discovered in some cultured cancer cell lines, including glioma (22, 23), ovarian (24, 25), liver (26), and prostate (27 — 29) cancer cells.
Norwalk, CT About Blog Get latest updates for oncologists and hematologists treating primary (astrocytoma, meningioma, medulloblastoma, ependymoma, brain stem glioma) and metastatic brain tumors.
Norwalk, CT About Blog Get latest updates for oncologists and hematologists treating primary (astrocytoma, meningioma, medulloblastoma, ependymoma, brain stem glioma) and metastatic brain tumors.
Norwalk, CT About Blog Get latest updates for oncologists and hematologists treating primary (astrocytoma, meningioma, medulloblastoma, ependymoma, brain stem glioma) and metastatic brain tumors.