Sentences with phrase «gliomas by»
To assess in a preliminary fashion the potential benefit of AdhCMV - TK and Ad - hCMV - Flt3L treatment of primary malignant gliomas by assessing overall survival (OS) at 12 and 24 months.
https://clinicaltrials.gov/
Newly diagnosed supratentorial brain lesion compatible with a high grade glioma by MR (magnetic resonance) with no prior treatment with either gene therapy, chemotherapy or radiation treatments that is amenable to attempted gross total resection (GTR).
Not exact matches
This approach has been investigated by TransMolecular, a company based in Cambridge, Massachusetts, as a way to treat glioma, a form of brain cancer.
A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3 K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG).
«We then evaluated the system in rats with glioma and found that by using a method called intracranial convection - enhanced delivery, our nanoparticles could penetrate completely throughout the tumor following a single injection,» says Jordan Green, Ph.D, associate professor of biomedical engineering and ophthalmology at Johns Hopkins.
The researchers comprehensively analyzed 254 TCGA lower - grade gliomas for gene, protein and micro RNA expression, DNA methylation and gene copy profiles to cluster cases by category.
In a study recently published in the journal Neuro - Oncology, a team of scientists led by Luni Emdad, M.B.B.S., Ph.D., and Paul B. Fisher, M.Ph., Ph.D., provided the first evidence of an important link between a specific microRNA, miR - 184, and a cancer promoting gene, SND1, in the regulation of malignant glioma.
Deadly brain tumors called high - grade gliomas grow with the help of nerve activity in the cerebral cortex, according to a new study by researchers at the Stanford University School of Medicine.
Dr. Sloan said, «The enhancing edge and the invading tumor are driven by glioma stem cells (GSCs) dependent on the EZH2 pathway.
«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.
They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.
Their paper, titled «Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator - based oximetry,» was published recently in the International Journal of Cancer.
Treatment of glioma has remained a challenge despite the options for surgical resection followed by chemotherapy and radiotherapy.
They also investigated a new strategy to significantly inhibit glioma growth by rationally combining gemcitabine and MK - 8776, a cell cycle checkpoint inhibitor.
A research team led by Christine Brown, Ph.D., and a clinical team headed by Behnam Badie, M.D., has received a $ 12.8 million grant from the CIRM to fund a phase 1 chimeric antigen receptor (CAR) T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.
Molecular testing: Some primary brain tumors, including some of the most common types of gliomas, are defined by their key molecular features resulting from tumor cell mutations.
Induction of a CD4 + T regulatory type 1 response by cyclooxygenase -2-overexpressing glioma.
Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration.
Molecular interaction and functional regulation of ClC - 3 by Ca2 + / calmodulin - dependent protein kinase II (CaMKII) in human malignant glioma.
Reber, F., Reber, U. and Funk, R.H. Intracellular changes in astrocytes and NG 108 - 15 neuroblastoma X glioma cells induced by advanced glycation end products.
With - No - Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume.
It was reported, for example, that CSC state could be maintained by overexpressing hypoxia - inducible transcription factor (HIF2α) in glioma cell lines [40].
The current standard of care for a newly diagnosed, high - grade glioma includes surgically removing as much of the tumor as possible, followed by radiation therapy and chemotherapy.
The first study by Bell and colleagues re-analyzed outcomes from a prior phase 3 study of anaplastic gliomas using a subset of molecular markers.
Finally, the study by Vera et al4 «demonstrates the power of combining clinical and molecular assessments in glioma studies to identify novel mechanisms underlying patient symptoms and toxicities for risk - stratification and interventions to improve patient outcomes.»
We show that Olig2 + oligodendrocyte precursor - like glioma cells invade by single - cell vessel co-option and preserve the blood - brain barrier (BBB).
Treatment of malignant glioma using gene transfer modalities typically consists of surgical debulking of the tumor mass followed by the administration of the viral vectors into the brain tissue surrounding the tumor cavity.
But a new nanotechnology approach developed by Xiaoli Liu and Madhan Kumar in the Department of Neurosurgery could transform gliomas from a death sentence into a treatable condition.
Winners of best award presentations from the event included: Best Avian / Exotics Presentation Dr. Mary Thurber - «Detection of Avian Boravirus in Captive Thick - billed Parrots (Rhynchopsitta Pachyrhyncha) by RT - PCR and ELISA» Best Large Animal Presentation Dr. Lisa Gamsjaeger - «Sodium Iodide as a Preventative Strategy for Respiratory Disease in Preweaned Dairy Calves» Best Small Animal Presentation # 1 Dr. Catherine Belanger - «High - Pressure Balloon Valvuloplasty for Severe Pulmonic Stenosis: A Prospective Observational Study in 25 Dogs» Best Small Animal Presentation # 2 Dr. Chai - Fei Li - «Exosome - Associated Integrins as Liquid Biopsy Biomarkers for Canine Glioma» Chris Smith Award Dr. Fauna Smith - «Eosinophilic Peritonitis in 8 Horses (1995 - 2015)» Gerald Ling Award Dr. Kate Farrell - «Evaluation of Pulse Oximetry as a Surrogate for Pao2 in Awake Dogs Breathing Room Air and Anesthetized Dogs on Mechanical Ventilation» UC Davis, with the largest resident training program of any veterinary hospital in the country, is able to offer unique research and publishing opportunities not available elsewhere to veterinarians pursuing advanced training at teaching hospitals.
Molecular Combinatorial Therapy for Canine Malignant Gliomas led by Dr. John Rossmeisl of the Virginia - Maryland College of Veterinary Medicine at Virginia Tech