Sentences with word «gliosis»

We therefore anticipated some improvement of gliosis in Grn − / − mice.

Histological assessment demonstrated reactive gliosis of both astro - and microglia in the spinal cord of end - stage disease SOD1 and PFN1 mice.

Focal gliosis occurred occasionally in the brain, with lymphocyte infiltration under cranial arachnoid (Fig. 3D).

(2008) Regulation of Gliosis in the DBA / 2J Mouse Model of Glaucoma by NF - kB and STAT3 Pathways (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5489).

Here one of our major hypotheses is whether gliosis is an aberrant regenerative response or an independent entity.

(2009) Tempering Gliosis by Inhibition of the NFkB Pathway in an Acute Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2781).

Müller glia are activated in almost all types of retinal disease, also called gliosis.

Grn − / −, but not Grn + / − mice, develop progressive gliosis, inflammation, and lipofuscinosis in several brain regions that first becomes detectable around 6 — 7 months of age and is more strongly elevated by 12 months (Ahmed et al., 2010; Yin et al., 2010; Wils et al., 2012; Filiano et al., 2013; Götzl et al., 2014).

We therefore included Grn − / − mice in the study to test the secondary hypothesis that exercise could improve gliosis independent of any effect on progranulin expression.

Grn − / − mice were included in the study to test for progranulin - independent benefits of exercise on gliosis.

Although it was not the primary endpoint of our analyses, we took the opportunity to assess whether exercise, which is known to have anti-inflammatory effects, might reduce gliosis and inflammation in Grn − / − mice, which would be independent of an effect on progranulin levels.

(2010) Decreasing Gliosis by Inhibition of the Stat3 Pathway in a Microbead Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3192).

In essence, most pathological conditions in the mammalian retina lead to changes in Müller glia — often called reactive gliosis, which might be analogous to the response of astrocytes upon injury of other brain regions.

HE - stained brain section showing focal gliosis (arrow)(D).

Here our major question is whether gliosis is an aberrant regenerative response or an independent entity.

The role of gliosis is controversial since it has been shown to provide neuroprotection and repair as well as being harmful by forming a glial scar (particularly the proliferative form)-- or possibly both.

Gliosis is a non-stereotypical response of glia associated with a pathological state that serves as an umbrella term describing various phenotypic changes.

Since the TMEM106B genetic variant on brain aging was also apparent in patients with Alzheimer's disease, Rhinn explained that «one interpretation is that TMEM106B is a critical element of a resilience network in the frontal cortex that limits the extent of neuronal loss and gliosis.»

While humans also have c - Fos, in humans the protein functions in concert with other proteins, in the JUN family, that cause cells to undergo reactive gliosis, which leads to scar formation.

Mock - infected control (A); Severe hemorrhage and regression of ovarian follicles (B); Spleens from mock - infected control (left) and enlarged spleens from the infected ducks (C); HE - stained ovary section showing hemorrhage and follicle rupture with red stained bodies (D); HE - stained brain section revealing lymphocytes and mononuclear cell infiltration under cranial arachnoid (E) and focal gliosis (arrow)(F).

In addition, the hippocampus of T2DM - AD - Vehicle mice showed increased proinflammatory cytokines IL - 1β and TNF - α and gliosis, and rivastigmine treatment blocked these inflammatory reactions.

Recent studies have suggested that cholinergic modulation is involved in neuroinflammatory cellular reactions including neurogenesis and gliosis, and in memory improvement.

For measures of gliosis in Grn − / − mice, we also reported the power to detect normalization of gliosis.

Keywords: Acetylcholinesterase, Alzheimer's disease, gliosis, high - fat diet, inflammation, memory, neurogenesis, rivastigmine, type 2 diabetes mellitus

Thus, cholinergic modulation by rivastigmine treatment led to enhanced neurogenesis and the suppression of gliosis, which together ameliorated the memory decline in T2DM - AD model mice.

Dr. Horner's experience in spinal cord injury and glial cells has been applied to glaucoma leading to new findings on the role of gliosis and oxidative stress in glaucoma.

Results: Both HFDs resulted in obesity and hyperleptinemia; however, the saturated HFD uniquely triggered anxiety - like behavior, behavioral despair, hyperinsulinemia, glucose intolerance, peripheral inflammation, and multiple pro-inflammatory signs in the NAc, including reactive gliosis, increased expression of cytokines, antigen - presenting markers and NFкB transcriptional activity.