Not exact matches
Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local
cellular adhesive, elastic and contractile properties are influenced by PCP
proteins and other molecules, and how they combine to produce specific packing geometries at a
global level.
To gain a deeper understanding of the
cellular response of the two neurotoxins, the researchers applied
global quantitative proteomics at the U.S. Department of Energy's national user facility — the Environmental Molecular Sciences Laboratory — and microarrays at UCLA to assay the
protein and gene levels, respectively, for both neurotoxins.
The researchers found that loss of collagen VII not only affected the composition of the
cellular microenvironment but also led to
global changes in cell homeostasis on mRNA and on
protein level.