Sentences with phrase «global changes compounds»

The convergence of local and global changes compounds the impacts on fragile but important high mountain ecosystems.

Not exact matches

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These frustrations, compounded by the growing need to understand global changes, have spurred researchers to design the Ocean Observatories Initiative (OOI)-- a $ 330 - million project that promises to herald the next generation of oceanographic study.

These changes have been compounded by stronger waves in the North Sea in recent decades, and could be further exacerbated if predictions that storminess will increase with global warming prove accurate.

Nonetheless, with rising sea level and environmental refugeeism compounding the increased demand on water, food, and land of a growing population (albeit one likely to level out mid 21st century), the combined impacts of climate change and global population increase could potentially yield a world that doesn't look that different from the one portrayed in the movie — indeed, as Jim Hansen puts it, «a different planet» — by century's end.

The current major global challenges in attaining food and nutrition security are compounded by pressures of growing populations, climate and other environmental change, and economic inequity and instability.

Although a reef manager can not easily address the global issues of increasing temperatures and acidification, managers can reduce local stressors that compound those associated with climate change and acidification.

where DTHx denotes the global mean surface temperature change after H years following an emission of compound x.

The GTP is defined as the ratio between the global mean surface temperature change at a given future time horizon (TH) following an emission (pulse or sustained) of a compound x relative to a reference gas r (e.g., CO2):

Bridlington, Whitby, and other English coastal towns have long depended on the North Sea fishery for food and income.2 But global warming is affecting plankton and changing the marine food chain, compounding the pressures of overfishing.3 The resulting disruption of the ecosystem could damage the fishing industry and hurt North Sea coastal communities from the United Kingdom to Scandinavia.

Now compound this massive propaganda failure by the anti-growth Democrats with this week's latest climate science news from the world's premier science journal and a leading global warming alarmist scientist: natural ocean oscillations are responsible for Earth's modern temperature changes, not human CO2.

The global annual mean surface air temperature change... centred at the time of CO2 doubling in a 1 % per year compound CO2 increase scenario.

According to the Intergovernmental Panel on Climate Change (IPCC) a global temperature rise of great than 2C would result in irreversible damage to society, including «increasingly dangerous forest fires, extreme weather, drought» as well as other compounding climate impacts.

Although we focus on a hypothesized CR - cloud connection, we note that it is difficult to separate changes in the CR flux from accompanying variations in solar irradiance and the solar wind, for which numerous causal links to climate have also been proposed, including: the influence of UV spectral irradiance on stratospheric heating and dynamic stratosphere - troposphere links (Haigh 1996); UV irradiance and radiative damage to phytoplankton influencing the release of volatile precursor compounds which form sulphate aerosols over ocean environments (Kniveton et al. 2003); an amplification of total solar irradiance (TSI) variations by the addition of energy in cloud - free regions enhancing tropospheric circulation features (Meehl et al. 2008; Roy & Haigh 2010); numerous solar - related influences (including solar wind inputs) to the properties of the global electric circuit (GEC) and associated microphysical cloud changes (Tinsley 2008).

Global mean temperature changes are driven by the global mean radiative forcing (RF) caused by each emitted comGlobal mean temperature changes are driven by the global mean radiative forcing (RF) caused by each emitted comglobal mean radiative forcing (RF) caused by each emitted compound.