The current
global cycle of glaciation dates to this period and might have been triggered by a transformation of the world's ocean currents, which a slender rib of land separating Atlantic and Pacific would naturally explain.
A new study of
the global cycle of these uranium isotopes brings additional perspectives to the debate on how Earth has changed over billions of years as revealed in a recently published study in the journal Nature.
Her interest is in understanding the mechanisms of metalloenzymes, especially those important in
the global cycling of elements.
Because of their combined mass, these animals also play a major role in
the global cycling of carbon from the atmosphere to the seafloor, she added.
Hynes noted that these represent huge steps forward but their effectiveness in protecting human health may be limited without an increased understanding of
the global cycling of atmospheric mercury.
Elbert, W., Weber, B., Burrows, S., Steinkamp, J., Büdel, B., Andreae, M.O., and Pöschl, U.: Contribution of cryptogamic covers to
the global cycles of carbon and nitrogen, Nature Geoscience, 5, 459 - 462, 2012.
However, despite their importance in biogeochemical processes, some of the paths comprising
the global cycles of N and P are not completely known30, 31.
According to new research by Thomas Weber, an assistant professor of Earth and environmental sciences at the University of Rochester, small microenvironments in the deep ocean may hold key clues to
the global cycling of nitrogen in seawater.
It's titled «The Evolution and Future of Earth's Nitrogen Cycle» and builds on earlier work showing how human activities have become a dominant influence on
the global cycling of a variety of substances.
Not exact matches
If we assume a 2 - year average upgrade
cycle for smartphones and growth trends remain the same, the
global smartphone installed base will grow from 2.2 billion in 2014 to about 4.2 billion by the end
of 2017, according to our estimates.
Low volatility shows that investors believe that long - term
global economic trends
of modest growth and tepid inflation will also define shorter - term
cycles.
Lakos - Bujas said he and his team view «normalizing inflation and declining
global deflationary risks as a positive for equities at this stage
of the
cycle, and believe there has been some overreaction to inflation headlines lately.»
But with monthlong high - tech - product life
cycles, just - in - time manufacturing operations, and overnight
global currency crashes, the business world might just be coming around to the marines» point
of view.
Pinker's extensively researched thesis is that
global violence has decreased throughout human history, as wrong as that may feel given the 24 - hour news
cycle that came into being not long after two world wars and matured during an age
of regular terrorist attacks and mass shootings.
This
cycle was partly caused by the explosion
of credit in the wake
of the 2008
global financial crisis.
This past November, the San Francisco - based Strava announced a huge update to its
global heat map
of user activity that displays 1 billion activities — including running and
cycling routes — undertaken by exercise enthusiasts wearing Fitbits or other wearable fitness trackers.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant
cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain
global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
The Q&A column looks at «Seven Questions on Turning Points
of the
Global Business
Cycle.»
While we still believe the
global expansion has room to run, we're also actively monitoring early signs
of potential overheating in the late
cycle environment.
Fears
of a
global trade war have been heating up in recent weeks... We've seen a
cycle of the U.S. announcing tariffs and investment restrictions on Chinese
Meanwhile, exports and investment are still weaker than one would expect at this stage
of the business
cycle, even though growth in the
global economy has also surprised on the upside.
As TMM mentioned last week there is a regional flavour as to opinion on China so perhaps we just need to get through a complete trading day
cycle before we get a true representation
of reaction, but TMM are going to stand by their guns as far as China goes and if we are going to start seeing some spurious euro trashing we will play this as a regional cross trade rather than a
global play.
Traditionally,
global equities do not peak until after the yield curve has inverted, he adds, but «given the very low - rate nature
of this
cycle, we'd expect a flat curve to weigh more heavily on sentiment and encourage a more defensive rotation.»
Yet, with key economies in different stages
of the business
cycle, «the risk
of the
global economy, or any of its major constituents, running too hot over the next 12 months is contained,» says Elga Bartsch, Co-Head of Global Econ
global economy, or any
of its major constituents, running too hot over the next 12 months is contained,» says Elga Bartsch, Co-Head
of Global Econ
Global Economics.
Rather, measures
of early improvement in market action that were effective across every post-war market
cycle quickly proved insufficient during the
global financial crisis.
That is exactly what happened, the lenders exhausted the pool
of borrowers, the reflexive impact
of rising demand pushing prices higher began to wane, and the virtuous
cycle turned dramatically (as they always do eventually) into a vicious
cycle that triggered the
Global Financial Crisis and those same banks that made all the ill - advised loans were crushed by massive losses Then, yet again, what were the «Masses» doing at the peak?
How central banks assess risks to price and financial stability will determine the pace at which they will withdraw monetary accommodation, one
of the key risks to the
global growth
cycle.
ECRI uses a highly nuanced «many -
cycles» view to understand the complex dynamics
of the
global economy.
Nimble short term tilts that seek to capitalize on opportunities or manage risks, based upon the strategic disciplined discussion
cycle of our
global investment committee.
We are in the early stages
of a
global reflation
cycle that started in mid-2016.
Global tech leadership for the next decade is at stake and ONLY the New T - Mobile will have the network and spectrum capacity to quickly create a broad and deep 5G network in the first few years
of the 5G innovation
cycle.
By: Victor Moolman 11th November 2016 South Africa is behind the
global curve when it comes to the integration
of mine closure and rehabilitation in the mining life
cycle with the historical approach
of mining companies being to focus predominantly on driving production, state consulting engineers and scientists SRK Consulting.
While this added flexibility gives managers the potential to outperform, it also requires a comprehensive understanding
of macroeconomic conditions and the experience managing flexible
global fixed income strategies across multiple market
cycles.
The great victory
of the Federal Reserve in the half -
cycle since 2009 was not ending the
global financial crisis; the crisis actually ended in March 2009 with the stroke
of a pen that changed accounting rule FAS157 and eliminated mark - to - market accounting for banks (instantly removing the specter
of widespread insolvencies by allowing «significant judgment» in valuing distressed assets).
The slowing in activity has been largely concentrated in the business and external sectors, consistent with the moderation
of the
global ITC
cycle and the easing in demand seen in other countries.
Goldman's
Global Leading Indicator's January reading and the latest revisions to previous months paint a significantly softer picture of global growth placing the global industrial cycle clearly in the «Slowdown»
Global Leading Indicator's January reading and the latest revisions to previous months paint a significantly softer picture
of global growth placing the global industrial cycle clearly in the «Slowdown»
global growth placing the
global industrial cycle clearly in the «Slowdown»
global industrial
cycle clearly in the «Slowdown» phase.
Financial constraints, investor bearishness, and the ever - lengthening time
cycle to build new mines will in our opinion lead to a moderate to severe decline in
global gold - mining output before the end
of the decade.
Michael Rawlinson,
Global Co-Head
of Mining and Metals at Barclays, commented that while the sharp drop in oil prices has reduced costs for mining companies it has also added to uncertainty in the market and could prolong the wait for the commodity
cycle to turn upwards again.
Trading FX and CFD products brings a number
of advantages, for example allowing investors to trade the full
global macro
cycle and hedge their market exposure in a flexible and efficient way.
The consolidation
of the
global resources industry may help to reduce the «cobweb
cycles» (or «hog
cycles») that periodically occur in commodity markets, but they are unlikely to eliminate such
cycles entirely.
However, the Fed's emphasis on downside risks is injecting a degree
of uncertainty — and volatility — into markets, a factor not lost on
global policymakers that are calling on the Fed to end its handwringing and begin the tightening
cycle.
Some investors now fear that the first quarter will be the peak earnings quarter
of the
cycle, given some one - off impacts from US tax reform and a modest slowdown in
global economic growth.
We have seen an expansion
of global high - yield debt issuance, particularly in European and emerging markets during this
cycle (as shown in Exhibit 1).
Future credit
cycles may not conform to historical patterns due to the growth and diversity
of global credit markets, financial innovation and regulatory changes.
Global oil producers were able to earn attractive full -
cycle rates
of returns on capital employed above $ 85 per barrel, but at current prices, the industry is being forced to significantly pare back drilling activity.
One may argue performance leadership
of Canadian versus
global equities runs in
cycles, which is a valid point.
The impact
of this
global expansion will likely be felt over subsequent
cycles, embedding new systematic risk factors for high - yield spreads.
Seventy percent
of investors polled by Bank
of America Merrill Lynch this month believe the
global economy is in «late
cycle» — the highest percent since January 2008.
During the last Fed tightening
cycle, long - term yields were held down by what former Fed Chair Ben Bernanke dubbed a «
Global Savings Glut» — a substantial excess
of desired savings over desired investment.
However, if the recovery in the
global private - investment
cycle, particularly in the U.S., proves stronger than we currently expect, it would support productivity growth, lift neutral real rates and encourage the Fed to take up an even faster pace
of rate hikes than we currently pencil into our base case.