Sentences with phrase «glucose uptake as»

The present study shows that the basal glucose uptake as well as insulin - stimulated GS activity is reduced in satellite cell cultures established from patients with type 2 diabetes.

Among the Indian Ayurvedic plant extracts, Kali musli (Curculigo orchioides) stimulated glucose uptake as well as reduced fat accumulation.

Not exact matches

The uptake of glucose by cells closely reflects their energetic needs, and is becoming poorly regulated in many pathological conditions such as obesity, diabetes and cancer.

In a recent study published in Angewandte Chemie International Edition, Associate Professor of Chemistry Wei Min's team developed a new glucose analogue that can mimic the natural glucose, and imaged its uptake as energy source by living cancer cells, neurons and tissues at the single cell level.

Glucose being supplemented with ketones, such as D - β - hydroxybutyrate or other substrate, could be one of the explanations for the decreased glucose uptake caused by exGlucose being supplemented with ketones, such as D - β - hydroxybutyrate or other substrate, could be one of the explanations for the decreased glucose uptake caused by exglucose uptake caused by exercise.

Using PET brain scans, they showed that those with impaired illness awareness also had reduced glucose uptake in specific brain regions, even when accounting for other factors linked to reduced glucose uptake, such as age and degree of memory loss.

To test how well FAHFAs could work as a potential therapy, the researchers fed the lipids to insulin - resistant mice, and observed an improvement in inflammation, insulin sensitivity and glucose uptake.

They found that GLUT1 deficiency led to diminished glucose uptake into the brain as early as two weeks of age and, by six months of age, neuronal dysfunction, behavioral deficits, elevated levels of amyloid - beta peptide, behavioral changes and neurodegenerative changes.

PI3K inhibitors are the subject of some 100 clinical trials, including one that will test whether a cancer treatment's early failure to reduce glucose uptake, as measured by FDG PET, can predict whether the therapy will fail to shrink a patient's tumor.

Before determining glucose uptake, all cell cultures were exposed to basal medium for 1 h. Cultures used for acute insulin stimulation were exposed for 1 h to high insulin as described for GS assays.

In healthy humans, skeletal muscle accounts for 70 — 80 % of the insulin - stimulated glucose uptake in vivo (23), and most of the glucose is stored as glycogen (24).

For example, mammalian insulin is secreted from pancreatic β - cells in response to high blood glucose levels; insulin is then received by its receptor in the liver as well as in many other tissues to promote glucose uptake and anabolism, thereby reducing blood sugar levels [1].

In cancer, elevated glucose uptake and high glycolytic rate, as source of ATP, constitute a growth advantage for tumors.

This is associated with modification of hypothalamic nitric oxide release that favors glucose uptake in metabolic tissues such as skeletal muscle, liver, and adipose tissue.

Besides bringing glucose into all cells in the body, insulin also helps in the uptake of amino acids into muscle tissue, which in turn initiates protein synthesis, and prevents amino acids from being oxidized as a reserve fuel source.

Insulin signals body cells to uptake glucose for energy, stimulates the formation of glycogen, and stimulates the conversion of glucose to triglycerides to be stored as fat.

Isoleucine can be seen as the BCAA which mediates glucose uptake (into a cell) and breakdown (into energy) to a larger degree than other amino acids and may serve a role as a hypoglycemic (in diabetics) or as a performance enhancer (if taken preworkout in a carbohydrate replete state).

Hence, the advent of sports drinks - fluids that contain electrolytes that your body needs, as well as glucose to continue fueling activity (and aid water / sodium uptake).

One interesting fact here is that many compounds are co-transported, for example sodium can not be efficiently absorbed without some sugars (remember this), as sodium uptake is coupled with glucose uptake, and absorption of both accelerates water uptake (as it forces water into the cells to buffer the two.)

It had long been believed that glucose uptake in the brain was entirely independent of insulin, as the common brain glucose transporters — GLUT1 and GLUT3 — are non-insulin-sensitive.

However, as is true of most biological mechanisms, context must be taken into account: acute administration of insulin improves performance on tests of memory and cognition, but chronically elevated insulin levels have the opposite effect.4, 42,43 This is akin to the pathology of T2D, in which normal, acute doses of insulin help regulate glucose uptake, but chronically elevated levels lead to insulin resistance, hyperglycemia, and the attendant inflammation and vascular damage.

(iii) Regional brain glucose uptake is impaired in AD and mild cognitive impairment (MCI), but brain uptake of ketones (beta - hydroxybutyrate and acetoacetate), remains the same in AD and MCI as in cognitively healthy age - matched controls.

Ongoing research also suggests that adding healthy fats and proteins, such as peanut butter or olive oil, to meals with foods that have a high GI may slow the uptake of glucose, thus, lowering the food's GI.

Because they increase insulin sensitivity as well as glucose uptake, they are useful to lower the blood glucose found in metabolic syndrome22.

It starts by improving insulin sensitivity in order to optimize postprandial glucose uptake and, as a consequence, minimize insulin signaling in the fasted state.

The Clamp method is recognized as the gold standard method, as it directly measures the body's uptake of glucose into tissue, but it is very expensive to perform.

RESULTS: In L6 muscle cells, short - term incubations (2 - 12 h) with 10 -LRB--3) m alpha - lipoic acid increased glucose uptake by 40 - 80 %, approximately the same extent as 10 -LRB--6) m insulin.

It increases the levels of neurotransmitters such as dopamine and acetylcholine; it boosts the uptake and use of glucose in brain cells; and improves communication between brain cells.

Participation in large amounts of sedentary, or sitting, behaviors is associated with multiple health problems such as impaired lipid profiles and glucose uptake, greater energy intake and waist circumferences, and greater mortality risk [2 — 6].

Symptoms of insulin resistance include decreased stimulation of muscle glycogen synthesis as well as defects in glycogen synthase activity and glucose uptake (18).