Levonorgestrel is hydroxylated in the liver and the metabolites are excreted as
glucuronide conjugates.
Supplementation with Calcium D - glucarate supports proper elimination of estrogen by inhibiting beta - glucuronidase, an enzyme produced by colonic microflora (e.g., E.coli) that hydrolyzes
glucuronide conjugates, thus returning estrogen into circulation.
Oral supplementation with calcium - D - glucarate has been shown to inhibit beta - glucuronidase, an enzyme produced by colonic microflora (e.g., E.coli) that is capable of hydrolyzing
glucuronide conjugates, thus returning estrogen readied for excretion back into circulation.