Sentences with phrase «glutamate receptors»
Glutamate receptors are proteins in our brain that help transmit signals between nerve cells. They play a crucial role in various brain functions, including learning, memory, and communication. Full definition
Yu LJ, Wall BA, Wangari - Talbot J, Chen S. Metabotropic glutamate receptors in cancer.
jbiomed.com
Pyroglutamate: experiments in rats show that this naturally occurring amino acid can stimulate a type of glutamate receptor in the brain — the NMDA receptor — which is thought to play a key part in learning.
The transport of NMDA glutamate receptors is a fundamental system that supports brain functions such as memory and learning.
Everitt suggests using an NMDA - type glutamate receptor blocker in the clinic could improve that treatment.
Another noteworthy finding is the detection of glutamate receptor genes (iGluRs)-- involved in rapid physiological response transmission — in sponges Corticium, Sycon, and Iricinia.
Previous studies have shown that drugs such as phencyclidine (PCP or «angel dust») and ketamine, which block glutamate receptors, cause schizophrenia - like symptoms in healthy volunteers.
The Groups II and III of glutamate receptor membranes are coupled to the intracellular G - protein subunit, these mediate the inhibition of adenylyl cyclase [40, 41].
These analyses revealed that expression of the metabotropic glutamate receptor family was also significantly enriched following hypoxia and recovery
mRNAs and protein expression for HIF - 1α, VEGF, nitric oxide synthase, and glutamate receptor subunits NMDAR1, GluR2, GluR3 were each found to be upregulated at 3 h and 24 h, but all returned to control levels by 14 days.
Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade.
GRID2 is a marker for a Purkinje - specific glutamate receptor.
Coruzzi hopes that these plant receptors could help identify new inhibitors of human glutamate receptors.
«Schizophrenia treatments targeting glutamate receptors have been tested in the past without success.
«While it still may be possible to optimize GlyT - 1 inhibition as a treatment, these negative results suggest GlyT - 1 inhibition is not a broadly effective or optimal therapeutic strategy to enhance NMDA glutamate receptor function in schizophrenia.»
Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber - spine synapses and absence from climbing fiber - spine synapses
The research group has ascertained that a molecule known as MAP1A connects NMDA glutamate receptors as they are being transported to the synapses to the microtubules, stabilizing the receptors and preventing them from becoming «derailed,» and playing a role in improving the overall efficiency and stability of the transport process.
Partin studies glutamate receptors in the brain.
GRIPANNT (Glutamate receptor interacting proteins as novel neuroprotective targets) 2005 — 2008.
For example, mercury increases extracellular levels of the excitatory neurotransmitter glutamate, thus overactivating glutamate receptors on cell surfaces.42 The amplification of glutamate is further exacerbated by mercury's inhibition of the calming neurotransmitter GABA.37 Mercury blocks GABA receptors, disproportionately destroys GABA - producing Purkinje neurons and impairs glutamate decarboxylase (GAD), the enzyme responsible for converting glutamate to GABA.
Among the most promising are the ampakines, a class of compounds that keep glutamate receptors open longer, allowing more of that critical neurotransmitter to enter the cell.
Gloria Coruzzi and her colleagues at New York University and the Chinese University of Hong Kong suspected that these toxins may also be part of plant signaling system, and so they set out to see if plants had proteins like glutamate receptors.
In a different sort of analysis, Pipes discovered that all aggressive foxes carry one form of the GRM3 glutamate receptor gene, while a majority of the friendly foxes have a different variant of the gene.
Consistent with recent studies of such changes, we find that long - lasting potentiation of synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GluR1.
Functional glutamate receptor (GluRs) were transiently expressed in cultured mammalian cells from cloned complementary DNAs encoding GluR - A, - B, - C, or - D polypeptides.
«One of the primary effects of ketamine in the brain is to block the NMDA [N - methyl - d - aspartate] glutamate receptor,» said James W. Murrough, MD, principal investigator of the study, and Assistant Professor of Psychiatry and Neuroscience, and Associate Director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai.
«It may be possible to improve the effectiveness of psychotherapy in people with PTSD by using glutamate receptor blockers during desensitization sessions when patients re-enact or remember the fearful situation,» says Haughey.
As calcium rushes into a memory neuron, PKMzeta is synthesized, linking up with spare glutamate receptors and dragging them to the synapse, where memory construction occurs.
The experience triggers a biochemical riot, causing a specialized glutamate receptor, called NMDA, to spring open and allow calcium ions to flood the cells.
The virus inserts the therapeutic gene into the cell's DNA and uses its instructions to produce a receptor protein — a modified version of a common glutamate receptor ion channel - that they display on their surface.
Single - channel analysis revealed that an adenosine 3», 5» - monophosphate - dependent protein kinase (PKA) increases the opening frequency and the mean open time of the non-NMDA-type glutamate receptor channels.
However, they might be more effective at treating patient groups with mutations in glutamate receptors such as GRM3.
Four cloned cDNAs encoding 900 - amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.
Researchers from the Kids Research Institute at the Children's Hospital, Westmead, and the University of Sydney detected antibodies to the dopamine D2 receptor or the N - methyl - D - aspartate (NMDA) glutamate receptor among eight out of 43 children experiencing their first episode of psychosis, but no such antibodies in healthy children.
Biophysical properties and responses to glutamate receptor agonists of identified subpopulations of rat geniculate ganglion neurons
The two «frontrunners», according to Dr. Buchanan, are ispronicline (nicotinic receptor partial agonist), and ORG 24448 (modulator of AMPA glutamate receptors).
Furthermore; it was observed that introduction of exogenous glutamate receptor membranes 1 into melan - A cells resulted in cell transformation in vitro and robust tumor formation in vivo [44].
Magdalena earned her PhD from Albert Einstein College of Medicine with Dr. Anna Francesconi, focusing on elucidating cellular / molecular players involved in regulation of dendritic spine morphogenesis by metabotropic glutamate receptor signaling.
Host: Dr. Cathy Rankin Speaker: Dr. Andres Maricq Title: CaMKII Regulates Motor - Mediated Transport of Synaptic Glutamate Receptors
University home > Centre for Synaptic Plasticity > Proteins interacting with glutamate receptors > AMPAR interactors
In this family, the metabotropic glutamate receptors respond specifically to glutamate, modulating neurotransmission on a slower time scale than the fast glutamate-gated ion channels [33].
Camilla Haglerød Glutamate receptor localization and trafficking in the glutamatergic synapse Faculty of Medicine, University of Oslo, 20 June 2008 Supervisor: Svend Davanger