Sentences with phrase «glutamate-gated ion channels»

The company's therapeutic candidates are highly selective sodium ion channel 1.7 (Naᵥ1.7) inhibitors based on naturally occurring small molecules.

The probablility of all the cellular machinery (enzymes, ion channels, RNA polymerase, anabolic and catabolic pathways, etc) just assembling out of randomn peptides and nucleic acids is infinitely small.

His team has been working on making systems that mimic natural ion channels, for example, but much bigger so that they can transport entire molecules.

Structure of the cold - and menthol - sensing ion channel TRPM8.

«We found that these neural crest cells contain temperature - sensitive ion channels that typically are found in your sensory neurons,» Benner said.

Vascular smooth muscle cells isolated from ERβ - deficient mice show multiple abnormalities of ion channel function.

Fast - acting neurotransmitters, e.g., glutamate (excitatory) and γ - aminobutyric acid (GABA)(inhibitory), achieve effects on their target cells within one millisecond by virtue of opening ligand - operated ion channels.

If the three - dimensional structures of the herb elements are elucidated, and a database of them can be established, it may facilitate computer - assisted imitation of docking between the herb element and physiologically important cell membrane proteins such as receptors, ion channels, and transporters.

The Fluc family of fluoride ion channels were recently discovered, and studies by a team led by Christopher Miller, PhD, HHMI Investigator and professor of biochemistry at Brandeis University, found that they are among the most selective channels yet identified.

«Monobodies are refined and powerful enough to attack important questions in biology and medicine, such as the structure of the fluoride ion channel, but they can also be used to generate molecules that are almost immediately useful in industry.

The researchers have designed a custom integrated circuit to perform these measurements, in which an artificial cell membrane and ion channel are attached directly to the surface of the amplifier chip.

BK channels are potassium ion channels found on the surface of a variety of cell types that are essential for the regulation of several key physiological processes, including smooth muscle tone and neuronal excitability.

Most typical ion channels have only one pore through which ions ¬ ¬ flow in the entire channel assembly, but the Fluc channel was found to have two.

«Synthetic proteins help solve structure of the fluoride ion channel: Unexpected double - barreled «channsporter» structure suggests new mechanism for ion transport.»

The ability to specifically block the ion channel with monobodies also raises intriguing possibilities for translational applications.

This leads to a large increase in the amount of a special calcium ion channel in the nerve cells and overall, this significantly boosts the risk of epileptic seizures.

A team of researchers at Columbia Engineering has used miniaturized electronics to measure the activity of individual ion - channel proteins with temporal resolution as fine as one microsecond, producing the fastest recordings of single ion channels ever performed.

When Lin's team repeated their experiment with nerve cells, they found that stimulating the quantum dots caused ion channels to open and the nerve cell to fire.

The potassium ion channel is critical to ending each heart contraction and is made up of the proteins Q1 and E1.

The OHSU scientists are interested in exploring another area of research focused on a type of ion channel in the membrane of neurons that is activated by serotonin.

Fluoride ion channels have only recently been discovered, and studies have hinted at an unusual structure that might explain their remarkable selectivity for fluoride.

In nerve cells, opening ion channels is a crucial step in generating action potentials — the signals by which the cells communicate in the brain.

Co-author Fred Reike, who specialises in retinal disease, says that quantum dots have great potential in this area because they directly affect ion channels, which play a key part in the signalling pathways of vision.

To avoid death, cells must remove fluoride that has accumulated inside them, a process accomplished via ion channels - protein tunnels through the cell membrane that only allow specific substances to pass through.

The researchers discovered that two members of a class of ion channels that can sense a change in temperature were present in neural crest cells from chickens and mice.

(Ion channels are passages through a cell's membrane that allow charged particles, or ions, into or out of the cell.)

Monobodies were engineered to function as «crystallization chaperones» that stabilized and aligned fluoride ion channels so their structure could be determined.

For the fluoride ion channel, the surface area that is covered by detergent compounds proved to be too much for crystal formation to occur, due to the channel's small size and almost complete embedment within the membrane.

The researchers discovered that the fluoride ion channel is comprised of two major building blocks, which assemble together in an antiparallel manner.

Ion channels are biomolecules that allow charged atoms to flow in and out of cells, and they are an important work - horse in cell signaling, sensing, and energetics.

«By designing a custom microelectronic amplifier and tightly integrating the ion channel directly onto the amplifier chip surface, we are able to reduce stray capacitances that get in the way of making fast measurements.»

To address this challenge, Koide, Miller and their teams designed monobodies that bound to target locations on the fluoride ion channel - specifically, two small surfaces not embedded within the cell membrane.

«With the structure now known, we can figure out exactly how fluoride ion channels work and how to control their function,» Koide said.

The N - methyl d - aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage - dependent sensitivity to magnesium and is modulated by glycine.

They use charge in the form of ions to carry energy and information — ion channels control the flow of ions across cell membranes.

Living systems achieve this functionality with their own version of electronics based on lipid membranes and ion channels and pumps, which act as a kind of «biological transistor.»

Thanks to past research he'd read about how random vibrations could open up neural ion channels, Wyss Core Faculty member James Collins discovered that those vibrations could improve seniors» motor control and balance when applied imperceptibly to soles of their feet.

«Biologically powered chip created: System combines biological ion channels with solid - state transistors to create a new kind of electronics.»

An ultraviolet laser frees the ATP, allowing it to rush into the ion channels of the modified neurons.

The CEO of another development - stage Cambridge biotech, Tim Brears of Xention, a discovery company specializing in ion channels, agrees that the recruitment market in the city suddenly has a very different feel.

«Small molecules are perhaps more affordable as treatments and can hit things like this ion channel switch, TRPM7,» said researcher Michael Schappe, a graduate student in Desai's lab.

This process, called ion channelling, is the focus of a new paper by Mallikarjuna Motapothula and Mark Breese working at the National University of Singapore.

Researchers experimented with different configurations for their remote control system, and they found the best relies on an iron nanoparticle (blue), which is tethered by a protein (green) to an ion channel (red).

Four HCN genes that code for proteins which form ion channels in neurons could be involved, because these channels are vital for electrical signalling in nerves.

When stimulated, the cells» channels open up within microseconds, much faster than most other ion channels in the body.

Peter Stern Senior Editor Education: M.D., University of Frankfurt Medical School; Ph.D., University of Heidelberg Areas of responsibility: Cellular and molecular neurobiology, cognitive neurobiology, systems neurobiology, ion channels, electrophysiology, neurological diseases, neuropharmacology E-Mail: [email protected]

Hair - cell physiologists don't know yet what the pore — called an ion channel — looks like, but some interesting biophysical properties suggest the channel is very fast and sensitive.

Motor rotation is powered by proton flow into the cell via ion channels.

The study, conducted by two teams at Duke University and appearing online Dec. 1 in the journal Neuron, is the first to connect autism to one of the most well - studied pain molecules, called TRPV1 (transient receptor potential ion channel subtype V1), which is a receptor for the main spicy component of chili peppers.

Birds, by contrast, seem to be impervious to capsaicin, apparently because they lack the right shape of a receptor — an ion channel — on their mucous membranes.