Sentences with word «glutamatergic»
The word "glutamatergic" refers to something that involves or relates to the neurotransmitter called glutamate. Full definition
Within her wider interest, Dr. Chartoff's laboratory focuses on sex differences in molecular and genetic contributions to addictive behaviors, the role of glutamatergic transmission in affective states and the role of kappa opioid receptors in drug withdrawal - induced depressive - like states.
mcleanhospital.org
Dr. Coyle's group used the SR - / - mouse model to explore the role of glutamatergic transmission in the regulation of 5 - HT2AR - mediated cellular and behavioral responses.
The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in glutamatergic synapse is a candidate gene for SCZ.
Jensen V, Rinholm JE, Johansen TJ, Medin T, Storm - Mathisen J, Sagvolden T, Hvalby O, Bergersen LH (2009) N - methyl - D - aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention - deficit / hyperactivity disorder Neuroscience, 158 (1), 353 - 64 PubMed 18571865
The lab uses genetic mouse models to characterize the mechanisms by which altered glutamatergic neurotransmission leads to pathological alterations in the brain, as a means to gain insight into the neurobiological underpinnings of schizophrenia.
memory process; hippocampo - cortical interactions; cholinergic system; glutamatergic system; Cellular and molecular biology; hippocampal neurogenesis; animal models of Alzheimer's disease; animal models of schizophrenia
The goal is to use this new understanding of the brain to develop novel and effective treatments for schizophrenia and other disorders of compromised glutamatergic signaling.
Gozzi, A. *, Large, C.H., Schwarz, A., Bertani, S., Crestan, V., Bifone, A. Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine (2008) Neuropsychopharmacology, 33 (7), pp. 1690 - 1703.
Specifically, we found that sleep - promoting KCs increase sleep by preferentially activating cholinergic sleep - promoting MBONs, while wake - promoting KCs decrease sleep by preferentially activating glutamatergic wake - promoting MBONs.
Glycine reuptake inhibitors have been considered a promising alterative to enhance glutamatergic signaling, and a small proof - of - concept study showed that bitopertin, which selectively inhibits glycine transporter type 1 (GlyT - 1), reduced negative symptoms in stable patients with schizophrenia.
Hevner and colleagues describe the cascade of transcription factors that are expressed during cortical development, and are hallmarks of glutamatergic neurogenesis.
In the hypothalamus, expressed in both GABAergic and glutamatergic presynaptic terminals of POMC neurons (at protein level)(PubMed: 25869131, PubMed: 25707796).
The acetylation changes were observed at genes that mediate glutamatergic function, specifically the glutamate receptor gene GRIA1, which has previously been implicated in drug use.
Three distinct classes of drugs: dopaminergic agonists (such as D - amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble schizophrenia symptoms in humans.
Cerebellin is a family of genes that physically interact with other autism genes to form glutamatergic synapses, the junctions where neurons communicate with each other via the neurotransmitter glutamate.
Notably, the ACC produces glutamatergic aversive teaching signals (14) that may regulate avoidance behaviors (15).
While less well established than dopamine, it is also likely that glutamatergic dysfunction also plays a role in psychotic disease.
Consistent with this, patch clamp recordings of these cells reveal glutamatergic synaptic transmission.
Immunocytochemistry now indicates that SR is expressed primarily in forebrain glutamatergic neurons with the remainder in GABAergic interneurons.
A promising glutamatergic drug for the treatment of substance use disorders is N - acetylcysteine (NAC), an amino acid cystine prodrug.
Abstract In the brain distinct population of inhibitory GABAergic interneurons innervate principal glutamatergic neurons to regulate various aspects of brain function.
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.
In 2007, we showed that astrocytes release adenosine to modulate glutamatergic synaptic transmission during hypoxia.
Chris P. Jew, Chia - Shan Wu, Hao Sun, Jie Zhu, Jui - Yen Huang, Dinghui Yu, Nicholas J. Justice, Hui - Chen Lu (2013) «mGluR5 ablation in cortical glutamatergic neurons increases novelty - induced locomotion», PLoS ONE, 8: e70415.
Elevated glutamatergic activity in the brain has been associated with aggression in animals and human [94].
Title: Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents Author: O. M. Doyle et al..
SHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses.
It is commonly argued that cholinergic receptors do not respond rapidly enough to be involved in generating theta waves, and therefore that GABAergic and / or glutamatergic signals (Ujfalussy and Kiss, 2006) must play the central role.
Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.
In - vitro brain slice recordings of both the R6 / 2 and Q175 mouse models of HD have revealed a paucity of glutamatergic innervation of the striatum as well as alterations in intrinsic membrane properties of striatal medium spiny neurons (MSNs, exemplified by a large increase in membrane resistance (Rm) and a reduced rheobasic current (Rh).
They also inserted the light - sensitive ion channels into a different set of neurons in the medulla: glutamatergic neurons, which release the neurotransmitter glutamate.
Male offspring showed stronger motivation to self - administer heroin during their adulthood and molecular changes in the glutamatergic system, which is the most important excitatory pathway for neurotransmission in the brain.
This suggests that specific pathologies and processes affecting D2R and the glutamatergic N - methyl - D - aspartate receptor (NMDAR) could define biological subgroups and may be involved in the pathogenesis of psychosis and other psychiatric illnesses such as schizophrenia.