The recent development of genetically - encoded fluorescent biosensors specific to glutathione (GSH), the most abundant cellular redox buffer, has facilitated the IGB research group's discovery of distinct alterations of
glutathione redox potentials in the cytosol versus mitochondria within the cell.
«The highly sensitive probe Grx1 - roGFP2 enabled us to monitor rapid compartmentalized changes in
the glutathione redox potentials in live cells.
Not exact matches
The team discovered that a compound called
glutathione — found in animal and plant tissues, including those of worms and humans — plays a very different role in
redox than originally thought.
Taken together, these findings indicate different
redox requirements for the
glutathione thiol / disulfide
redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their
redox poise in response to inhibition of
glutathione biosynthesis.
Dr. Steven R. Goodman, Editor - in - Chief of Experimental Biology and Medicine, said «Kolossov et al have utilized a genetically - encoded
redox probe that has the ability to determine oxidized / reduced
glutathione levels within different cellular compartments of living cells.
Determination of
glutathione in lymphocytes and possible association of
redox state and proliferative capacity of lymphocytes.
The
redox couple between
glutathione and ascorbic acid: a chemical and physiological perspective.