Sentences with word «glycan»
Across the hall at KSU, Dr. Clayton Buck's laboratory was doing pioneering work on the roles of glycans in cancer.
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We document that αMβ2 is a lectin that recognizes exposed β - N - acetylglucosamine residues of N - linked glycans on GPIbα.
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
5/19/2008 Mystery Solved: The Ashwell Receptor Reduces Mortality During Bacterial Infection In research that solves the longest - standing mystery in glycobiology — a field that studies complex sugar chains called glycans — researchers at the University of California, San Diego School of Medicine have discovered that a molecule in the liver o...
These modules recognise a specific sugar molecule, sialic acid, which caps the end of mucin glycan chains.
All living cells assemble a diverse repertoire of glycan structures on their surface via their glycosylation machinery.
This image from the work shows the binding of avian - like glycan receptors (yellow spheres) to the 2013 H7N9 influenza virus hemagglutinin (in ribbon diagram).
The MGH team set out to determine whether administration of a transferase, an enzyme that moves chemical groups like glycans from one molecule to another, could convert inflammatory antibodies to anti-inflammatory forms within a living animal.
The MGH team set out to determine whether administration of a transferase, an enzyme that moves chemical groups like glycans from one molecule to another, could convert inflammatory antibodies into anti-inflammatory forms within a living animal.
Infantis reveal a preference for host glycans.
While ancient fossils from hominins are not yet available for glycan analysis, this proof - of - concept study, published September 11, 2017 in Proceedings of the National Academy of Sciences, may set the stage for unprecedented explorations of human origins and diet.
These mucin glycan chains provide a source of nutrients as well as an attachment site for bacteria that have evolved to colonise the outer mucus layer.
Cell surfaces are more natural than glass slides for identifying glycan - protein interactions
Boris Brumshtein, Paul Salinas, Brian R Peterson, Victor Chan, Israel Silman, Joel L Sussman, Philip J Savickas, Gregory S Robinson, and Anthony H Futerman (2010) Characterization of gene - activated human acid - β - glucosidase: Crystal structure, glycan composition, and internalization into macrophages.
In addition, other types of bacteria in your mouth use sugars to produce glycan strands, which cause thick layers of plaque on your teeth and gums.
The scientists found that on the HIV envelope protein, at a site important for viral function, a small group of sugar molecules, known as glycans, serves as a key «anchor» for antibodies that can broadly neutralize the virus.
Bone broth protein is rich in collagen protein, glycosamino glycans, chondroitin sulfate, proline, glycine and L - glutamine.
By contrast, non sub-type B virus favor the production of antibodies which bind to a sugar element of the virus spikes (V2 glycan).
The TSRI scientists are continuing to study bnAbs against HIV for clues to an effective vaccine design, but as new candidate vaccines are developed, targeting V2 apex glycans is likely to be a high priority.
Research Interests: Inflammatory bowel disease; inflammation; leukocyte adhesion; platelet hyaluronidase; Human milk glycans; hyaluronan; intestinal protection; beta defensins; Salmonella infection;
For millions of years, the common ancestors of humans and other apes shared a particular glycan known as Neu5Gc.
For many years inadequate technologies have hampered our understanding of glycan complexity.
GlycoPAT includes advances in glycan identification, scoring schemes and false discovery — rate calculation.
And it's one of the most healing foods for your body, as it's chocked full of gelatin, collagen, hyaluronic acid, chondroitin sulfate, glucosamino glycans, and lots of minerals like calcium, potassium, magnesium, and phosphorus.
The latter are structurally diverse unconjugated glycans that are highly abundant in and unique to human milk; they can stimulate the growth and / or activity of healthy intestinal bacteria.
With the new method, scientists can finally see which types of glycans make up the glycoprotein — and whether the glycoprotein has any vulnerable holes.
The researchers used their new method to create a map of the surface glycans on an HIV vaccine candidate glycoprotein.
Bifidobacterium are known to consume the 2» - fucosylated glycans (sugars) found in the breast milk of women with the fucosyltransferase 2 mammary gene.
«First, these findings tell us that this mucus made up of O - glycan sugars is essential for preventing the development of colitis and colon cancer,» said Xia, who holds the Merrick Foundation Chair in Biomedical Research at OMRF.
What's more, MPI - CBG postdoc Katie Long noticed that the three proteins formed folds only after they clustered with another complex glycan molecule called hyaluronic acid.
VRC26 antibodies bind specifically to a hard - to - reach but relatively unvarying viral protein sequence, as well as to two nearby glycans.
In collaboration with investigators from the University of Copenhagen and University of Chicago, the researchers developed novel CAR T cells that express a monoclonal antibody called 5E5, which specifically recognizes a sugar modification — the Tn glycan on the mucin 1 (MUC1) protein — that is absent on normal cells but abundant specifically on cancer cells.
Whether activated antibodies stimulate an inflammatory or anti-inflammatory response appears to be determined by specific sugar molecules called glycans attached to the Fc region — the tail - like section of a Y - shaped antibody.
While glycans are usually attached to the proteins making up antibodies while they are being assembled within cells, recent evidence suggests they could be modified outside of the cellular environment.
Bt shifts its metabolism from mucosal glycans to dietary plant polysaccharides when in the presence of Bifidobacterium animalis, Bifidobacterium longum, or Lactobacillus casei (Sonnenburg et al, 2006).
Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development.