In this recent study, scientists determined that
glycation damages macrophage migration inhibitory factor (MIF) enzymes in early Alzheimer's.
Not exact matches
Over a lifetime, an overactive immune system will contribute to an overproduction of AGE's, advanced
glycation end products, initiating oxidative reactions within cells that will gradually
damage organs throughout the body.
Sugar has no nutritive value and raises blood glucose levels, stimulating the release of insulin as well as the formation of advanced
glycation end products (AGE's) which can
damage skin collagen and lead to wrinkles, among many other issues.
«Too much sugar in your diet will lead to an age accelerating process in your body known as
glycation and
glycation does
damage to the collagen in your skin making you lose skin elasticity causing wrinkles to appear,» affirms Dr. Calapai.
The test, which could be available to patients within two years, identifies the chemical signatures found in the plasma of blood joint proteins
damaged by oxidation, nitration and
glycation; the modification of proteins with oxygen, nitrogen and sugar molecules.
High advanced
glycation end - products overwhelm innate defenses of enzymes and receptor - mediated endocytosis and promote cell
damage via the pro-inflammatory and pro-oxidant receptor for advanced
glycation end - products.
Advanced
glycation end - products promote oxidative
damage to proteins, lipids and nucleotides.
Glycation causes
damage to the body's proteins, which can result in inflammatory diseases like arthritis, fibromyalgia, and dementia.
These
damaged proteins are called advanced
glycation end products (AGEs).
Diabetics, for example, may suffer from poor bones, not because of low mineral density but because their collagen is
damaged by the advanced
glycation end products (AGEs) created when blood sugar levels are chronically high.
-- Sugar and processed grains cause high blood sugar which causes «
glycation», which
damages our skin by causing age spots and wrinkles.
Besides oxidation,
glycation and the subsequent formation of AGEs is one of the major molecular mechanisms causing ongoing
damage in your body, which leads to disease, (premature) aging and, eventually, death.
This has several positive effects, here's a few: (a) because blood sugar levels are low, there won't be any further
damage to cells from
Glycation (high blood sugar kind of «fries» a cell, like a grilled cheese sandwich — literally.)
When faced with these daily stressors the PUFAs would be a detriment to all aspects of defending the brain / body from said stressors as they disrupt many vital hormonal signalling pathways,
damage lipoproteins, make us more sensitive to sunlight, accelerate
glycation, and less resistant to social stress.
Given the quantity of sugar consumed, fructose
damages the liver by
glycation and the carbs increase fat storage in the liver.
Those massive spikes in your blood sugar essentially
damage your cells in your body through a process called
glycation, which accelerates the rate of aging in your joints, skin, organs, and even your brain.
Elevated blood sugar leads to
glycation (basically, oxidation and caramelization of blood sugars), which leads to sticky sugar - protein and sugar - lipid complexes that
damage the lining of the blood vessels and other organs leading to their dysfunction.
The biological mechanisms of lifespan extension through calorie restriction are not fully understood, but researchers say it may involve alterations in energy metabolism (as mentioned above), reduced oxidative
damage, improvements in insulin sensitivity, reduction of
glycation, modulation of protein metabolism, downregulation of pro-inflammatory genes and functional changes in both neuroendocrine and autonomic nervous systems.
Extra padding in the abdominal region prevents the body from properly utilizing insulin; as a result glucose begins to build up in the blood, which causes
glycation -
damage to internal organs and blood vessels.
Increases advanced
glycation end products wherein sugar molecules attach to proteins and end up
damaging them
Potential applications Skin health — anti-ageing (wrinkles, lines, sagging skin, age spots, collagen
damage, broken capillaries, acne, enlarged pores, under - eye bags and puffiness) Insulin resistance (syndrome X) and
glycation conditions.
High blood sugar also causes the formation of advanced
glycation end - products (AGEs)-- nasty little compounds that speed up the aging process and
damage tissues (especially the skin, in the form of wrinkles and lost elasticity).
Surplus glucose relentlessly reacts with your body's proteins, causing
damaging glycation reactions while fueling the fires of chronic inflammation and inciting the production of destructive free radicals (Basta 2004; Uribarri 2005; Toma 2009).
In addition, to stop the
damaging «
glycation» reactions that can take place when dietary carbohydrates react with proteins in the body, you can also take about 50 - 100 mg daily of vitamin B6 pyridoxine, which most multi-vitamins contain (and meal replacement powders like LivingFuel SuperGreens).
Jaminet has admitted as much by stating below, «the number of
glycation reactions may be proportional to the concentration of glucose, and if
glycation products are health
damaging toxins then toxicity may be proportional to glucose levels..»
This view makes sense as a matter of molecular chemistry: the number of
glycation reactions may be proportional to the concentration of glucose, and if
glycation products are health
damaging toxins then toxicity may be proportional to glucose levels.
... and many studies have been found that show that, at least for a short period of time,
damage from
glycation and other adverse molecular events occur with far lower blood glucose.
The high blood sugar causes
damage to proteins (AGE or Advanced
Glycation End - Products), which then raise the risk of dying.
Indeed,
glycation events have been shown to be very
damaging to health.
«the number of
glycation reactions may be proportional to the concentration of glucose, and if
glycation products are health
damaging toxins then toxicity may be proportional to glucose levels..»
Here's how: sugar triggers «
glycation issues» that can
damage the collagen in your skin and lead to wrinkles and sagginess.
As a bonus, olive leaf extract protects against the
damage of high blood sugar — against advanced
glycation end products (AGEs), free radicals which form when elevated blood glucose levels react with proteins and run wild.
The bulk of the age - related tissue
damage classified as «
glycation end - products» (or «advanced
glycation end - products,» AGE) is produced by decomposition of the polyunsaturated fats, rather than by sugars, and this would be minimized by the protective oxidation of glucose to carbon dioxide.»