Sentences with phrase «glycerophosphodiester phosphodiesterase»

Most of the postsynaptic nerve endings showed phosphodiesterase activity.

The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane.

Using this material, the researchers were able to analyse in detail the response of rhodopsin, the pigment protein underlying vision, and phosphodiesterase, and for this reason they believe it can be useful in the field of optogenetics in the future.

The magnitude of this signal is restricted by desensitization of the receptors through their binding to β - arrestins and by cAMP degradation by phosphodiesterase (PDE) enzymes.

Drugs tested by the U-M appear to correct the signaling pathway that is disrupted in muscular dystrophy at an earlier step than the phosphodiesterase inhibitors.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase — which mediate phototransduction, the process of converting light into an electrical signal.

Probing further, the authors of the study also revealed that Aipl1 is critical for the stability of two enzymes — the cGMP - phosphodiesterase 6 and the guanylate cyclase - which mediate phototransduction, the process of converting light into an electrical signal.

The presentation, entitled «Ibudilast — Phosphodiesterase Type 4 Inhibitor — Bi-Modal Therapy with Riluzole in Early Cohort and Advanced Amyotrophic Lateral Sclerosis (ALS) Patients — Final Report and Future Directions «(Source) will be presented by principal investigator of the clinical study, Dr. Benjamin Rix Brooks, of the Carolinas HealthCare System's Neuromuscular / ALS - MDA Center at Carolinas HealthCare System Neurosciences Institute.

The finding was supported by a structural comparison of various members of the diverse phosphodiesterase family.

The paper, entitled «The Phosphodiesterase 4D gene confers risk to ischemic stroke,» by a deCODE - led team of scientists headed by Solveig Gretarsdottir, is accessible at http://www.nature.com/ng/, and will appear in the October issue of the print edition of the journal.

Distinct phosphodiesterase - 4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes.

Reduced phosphodiesterase 3 activity and phosphodiesterase 3A level in synthetic vascular smooth muscle cells: implications for use of phosphodiesterase 3 inhibitors in cardiovascular tissues.

Compartmentalized phosphodiesterase 4D isoforms expression, targeting and localization in vascular myocytes.

The team knew that Zucchini — and its analog in mice, called mouse Zucchini (mZuc, previously called PLD6 / MitoPLD)-- belongs to an enzyme family called phosphodiesterases.

Vascular smooth muscle cell phenotype - dependent phosphodiesterase 4D short form expression: role of differential histone acetylation on cAMP - regulated function.

A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.

Molecular cloning has demonstrated that dunce codes for the enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl cyclase; DCO codes for the catalytic subunit of protein kinase A, and CREB a transcription factor that is phosphorylated and activated by protein kinase A.

The phosphodiesterase 4D gene confers risk to ischemic stroke.

Substrate specificity of tyrosyl - DNA phosphodiesterase I (Tdp1).

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

Design and synthesis of fluorescent substrates for human tyrosyl - DNA phosphodiesterase I. Nucleic Acids Res.

We are currently studying viral and host 2», 5» - phosphodiesterases that prevent activation of RNase L, thus allowing virus replication and viral pathogenesis.

Concordantly, inhibition of the cGMP - dependent protein kinase G (PKG) blocks egress induced by PKAc1 inactivation or environmental acidification, while a cGMP - phosphodiesterase inhibitor circumvents egress repression by PKAc1 or pH neutralisation.

Among the top hits was a variant adjacent to the gene for PDE10A, a cyclic nucleotide phosphodiesterase involved in regulating smooth muscle contraction, including the muscles that surround the spleen.

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution.

Pfizer's new drug («MP - 10») targets something called «phosphodiesterase - 10A».

Some medications include oral steroids, phosphodiesterase - 4 inhibitors, theophylline and antibiotics.

The drug Viagra works mechanistically as a phosphodiesterase inhibtor to enhance nitric oxide.

Epimedium PDE - 5 Inhibitor Icariin from Epimedium extract is the only natural plant substance that has been observed to inhibit PDE5 (cGMP - specific phosphodiesterase type 5).

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Chocolate contains methylxanthines and phosphodiesterase inhibitors, which can cause vasoconstriction (tightening of veins), increased heart rate and central nervous system stimulation.

It is classified as a vasodilator as well as a phosphodiesterase type V inhibitor.1 The 2 other medications that are used for erectile dysfunction (vardenafil and tadalafil) act similarly.

The inhibition of phosphodiesterase V leads to an increase in cGMP; this causes smooth muscle relaxation, which then leads to a decrease in blood pressure (hypotension).1 If the patient suffers from preexisting hypotension or is taking medications that can decrease blood pressure, sildenafil can intensify the effects.

This medication is a phosphodiesterase III inhibitor.

PRA in the Cardigan Welsh corgi, termed rod - cone dysplasia 3 (RCD3), is also caused by a mutation in a subunit of cGMP phosphodiesterase, this time the alpha subunit, which results in a disease with a comparable age of onset to RCD1 [4].