Finally, they equipped the nanoparticles with polyethylene
glycol molecules, which allow them to resist the internal defenses of a tumor cell.
Not exact matches
With this in mind, scientists from the Center for Nanomedicine at Johns Hopkins, led by Hanes, encapsulated the BPTES in a nanoparticle capsule coated in polyethylene
glycol, a
molecule used widely in medicines and industrial products, using a method they developed to provide a more uniform coating.
Simultaneously, cryoprotectants that are made up of smaller
molecules such as ethylene
glycol or glycerol are able to permeate the cell so it doesn't shrink up like a raisin.
Most of the 140 types of
molecules found in space have been discovered here, including some common on Earth: acetic acid (vinegar), ethylene
glycol (the chief ingredient in antifreeze), and a basic sugar known as
glycol aldehyde.
GNA (
glycol nucleic acid) is even simpler than TNA, with just three carbon atoms in its backbone, yet can still form helical
molecules, much like DNA (The Journal of Organic Chemistry, DOI: 10.1021 / jo201469b).
Instead of marrying the clotting proteins to a natural substance in the body, they are attached to synthetic polyethylene
glycol (PEG)
molecules (see «PEGylation protection»).
Before injecting nematodes with magnetic nanoparticles, the scientists first coated the manganese — iron nanoparticles with polyethylene
glycol, a
molecule that targeted the particles to the mucus layer of the amphid region (an opening near the nematode's mouth that hosts the nerve cells involved in the heat avoidance reflex).
Once the
molecule is borylated, the boron substituent can be replaced by other substituents, in this case, by an aromatic
molecule bearing highly soluble tetra (ethylene
glycol) chains (TEG).
The scientists used polyethylene
glycol as the synthetic
molecule, adding a lectin group as an «anchor.»
Ethylene
glycol (a 10 - atom
molecule made up of carbon, hydrogen, and oxygen) is one of the five largest
molecules ever discovered in space.
Signals from other
molecules can sometimes fall at nearby frequencies, in effect smudging the ethylene
glycol fingerprint.
«Though we most commonly think of ethylene
glycol as antifreeze, it actually is associated with the formation of more complex sugar
molecules that are necessary for life,» said Jan M. Hollis of NASA Goddard Space Flight Center in Greenbelt, Maryland.
Pharmaceutical companies capitalize on this property by mixing or chemically binding drug
molecules to propylene
glycol to increase the drug absorption rate (source).
Our cell membranes are made with thin layers of fat
molecules, which can be easily disrupted by surfactants like propylene
glycol.
Cells exposed to propylene
glycol become more permeable to other
molecules (source).