Sentences with word «glycolipid»

«One of the goals in this field has been to identify compounds that elicit a more biased or selective response from iNKT cells, and we were able to incorporate features in AH10 - 7 that did that,» says Howell, who has been studying the role of glycolipids in modulating the human immune system for more than 20 years.

I discovered that hopanoids interact with glycolipids in bacterial outer membranes to form a highly ordered bilayer in a manner analogous to the interaction of sterols with sphingolipids in eukaryotic plasma membranes (Saenz et al., 2015).

Efforts to harness the therapeutic potential of human iNKT cells began 20 years ago with the discovery that natural and synthetic forms of glycolipid ligands known as alpha - galactosylceramides, or?

Cholesterol modulates glycolipid conformation and receptor activity.

B., Róg, T., Vattulainen, I., Grzybek, M., Coskun, Ü., Lingwood, C.A., Simons, K. Cholesterol modulates glycolipid conformation and receptor activity.

The Morita lab is expert in investigating the multi-layered cell envelope components that surround mycobacteria, including several glycolipids known or predicted to be essential for the overall viability of disease - causing Mycobacterium tuberculosis (Mtb), which have impermeable cell walls that block antibiotics.

It turns out that the «mutant mutant» has an initial growth defect plus another mutation in the same glycolipid biosynthesis pathway and the second mutation allows these bacteria to enjoy more normal growth.

«Antibodies recognize a certain glycolipid structure present at the cell membrane of the bacteria.

«The mutated gene caused the production of different glycolipids in the mutant of the mutant.»

Research Focus: My research projects are focused on detection of antigenicity of complex glycolipids that trigger cytokines production by NKT cells.

The laboratory focuses on a subset of T cells, that recognize glycolipids, or combinations of sugar and fat.

More recent work has shown that glycolipids capable of stimulating Vα14 iNKT cells are found in several types of bacteria, including the relatively nonpathogenic and ubiquitous species of Sphingomonas organisms, and the spirochete Borrelia burgdorferi, which causes Lyme disease.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Glycolipids provide energy and serve as markers for cellular recognition.

The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism.

The disrupted lysosomal degradation and resulting storage of HS and glycolipids such as gangliosides leads to severe neurodegeneration.

Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex ‐ germ ‐ free mouse

In the past I have worked in the development of computational methods for mass spectrometry data analysis, particularly in the identification of glycolipids and proteins.

Hyaluronic Acid, Panthenol, Glycolipids and Algae Extract help restore moisture balance.

Understanding how the bacteria make these glycolipids might provide us a way to interfere with them and stop them from being able to infect us.»

As part of the long effort to improve treatment of tuberculosis (TB), microbiologists led by Yasu Morita at the University of Massachusetts Amherst report that they have for the first time characterized a protein involved in making a glycolipid compound found in the TB cell wall, which is critical for the disease - causing Mycobacterium to become infectious.

«This led us to the discovery of a new gene in the biosynthesis of this glycolipid, which we termed lipomannan elongation factor or LmeA,» Rahlwes says.

If they don't have it, the enzymatic machinery they use to biosynthesize the glycolipid won't work, and they can not become infectious.

[i] Furthermore, [we] demonstrated that an MHC like molecule, called CD1d, loaded with a glycolipid ligand, called alphaGalCer, also targeted to the tumor cells by monoclonal antibodies, was capable to specifically inhibit tumor growth in vivo and to give a sustained activation of the Natural Killer Cells known to be important in the innate immunity.

A glycolipid that activates these cells is currently in clinical trials in Australia, Japan, and Europe for treatment of metastatic cancer and hepatitis C virus infection.

Previous data from our laboratory and others have determined that Vα14 iNKT cells respond to glycolipids with defined structures, including a ceramide lipid backbone and an α - linked hexose sugar, when presented by CD1d.

Sialic acid is a negatively charged sugar localized at the end of glycoconjugate chains on glycoproteins and glycolipids.

Using standard enzyme - linked immunosorbent assays (ELISA) and peripheral blood mononuclear cell (PBMC) assays, researchers discovered that unlike previously described human antibodies to lipids, WR321 did not react with any of 17 other lipids it was tested against, including cholesterol, glycolipids, and other phospholipids such as cardiolipin and phosphatidylserine, but it bound specifically only to two phosphoinositides.

In addition to stem cell transplants, which have been used for decades, the immunotherapeutic antibody dinutuximab ⎯ which targets the glycolipid GD2 ⎯ is approved for childhood cancer patients with neuroblastoma.

Glycolipids are lipids with a carbohydrate attached.

His postdoctoral research and his Ph.D. studies were centered on the biochemistry and function of glycolipids.

More than 20 different intralesional therapies, ranging from viruses and cytokines to glycolipids, plasmids, antibodies, and small molecules, have been tested in clinical trials for metastatic melanoma alone.

And if you're looking for another reason to supplement your diet with spirulina, this superfood is rich in phytonutrients including chlorophyll, polysaccharides, sulfolipids, and glycolipids.

This process results in glycolipids and glycoproteins that make up cell walls and are vital to intercellular communication.

Glycolipids are sugar - fat molecules found in foods like broccoli, cabbage, brussel sprouts, kidney beans, and lentils.

Lipids The lipid content of Australian Sweet Lupin comprises of triglycerides (71 %), phospholipids (15 %), free sterols (5 %), glycolipids (3.5 %) sterol and wax esters (0.5 %), free alcohols (0.4 %) and unidentified waxy material (4 %).

In fact, oil, wax, phospholipid, glycerol, glycolipid, steroids, terpenes... all of these terms refer to fats!

Because these substances act as anti-inflammatories and favor the production of glycosaminoglycans, they therefore include that of proteoglycans and glycolipids; in fact, chondroitin sulfate is a type of glycosaminoglycan.