Sentences with word «glycosphingolipid»

We hypothesized that certain lectins link glycosylated cargo proteins and glycosphingolipids into molecular nanoenvironments from which endocytic pits are formed without the help of the cytosolic clathrin machinery (Figure 1).

The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis.

We have also set out to exploit the specificity of carbohydrate recognition and the ensuing membrane mechanical potential resulting from clustering of glycosphingolipids for the development of innovative therapeutic delivery strategies for the treatment of cancer and infectious disease.

Its nontoxic B - subunit binds to the cellular toxin receptor, glycosphingolipid Gb3, which is highly expressed on human cancers and has recently been reported to be involved in the formation of metastasis in colorectal cancers.

Lakshminarayan R, Wunder C, Becken U, Howes MT, Benzing C, Arumugam S, Sales S, Ariotti N, Chambon V, Lamaze C, Loew D, Shevchenko A, Gaus K, Parton RG, Johannes L (2014) Galectin - 3 drives glycosphingolipid - dependent biogenesis of clathrin - independent carriers.

382/12: 15 B4GALNT1 deficiency as a cause of hereditary complex movement disorder with Parkinsonism features: A new inborn error of metabolism affecting glycosphingolipid biosynthesis.

The animal fats also supply other fat soluble nutrients that support the immune system such as glycosphingolipids.

It contains glycosphingolipids which prevent intestinal distress and conjugated linoleic acid which has strong anticancer properties.

These were sphingolipids (35 %); phospholipids (26 %); glycosphingolipids (9 %); purines (5 %); microbiome (5 %); and P5C, Arg, and Pro (3 %).

These were sphingolipids (49 %); phospholipids (16 %); P5C, Arg, and proline (Pro)(7 %); glycosphingolipids (6 %); and cholesterol (4 %).

Sebastian Boland (Kurzchalia, MPG)-- «Regulation of Caenorhabditis elegans Development by an Interplay between Sterols and Glycosphingolipids» (2014)

The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells.

Here, we tested whether human gastric cancers, which are among the most aggressive tumor entities, express the cellular receptor of Shiga toxin, the glycosphingolipid globotriaosylceramide (Gb3 / CD77).

We have validated the glycosphingolipid - binding non-toxic B - subunit of Shiga toxin as a delivery tool for cancer immunotherapy, and are currently building therapeutic vaccine prototypes for breast and head - and - neck cancers.

Glycosphingolipids: This type of fat protects against gastrointestinal infections, especially in the very young and the elderly.