Sentences with word «glycosylation»

Nine monosaccharides are used in the enzymatic process of glycosylation in mammals.

His research interests in the laboratory include thyroid hormone action in the heart, as well as studies related to diabetic cardiomyopathy and the effects of excessive enzymatic protein glycosylation in cardiac myocytes and their influence on heart function.

[13] Mechanisms that may account for lipoic acid's benefit in preventing diabetic complications include prevention of protein glycosylation [14] and inhibition of the enzyme aldose reductase, the latter of which subsequently inhibits conversion of glucose and galactose to sorbitol.

Abdel - Mohsen's research focuses on investigating the role of host glycosylation machinery in viral persistence and immunopathogenesis.

This suggests that host glycan - lectin interactions likely mediate signals that define, in part, the transcriptional state of HIV and that host glycosylation machinery may be exploited to develop novel HIV therapeutic strategies.

(Hemomglobin A1C is a form of the key protein in our red blood cells — hemoglobin — in which the protein gets linked up with a sugar molecule through a process called glycosylation.

Any predicted N - linked glycosylation sites were systematically removed by substituting alanine for serine / threonine at these sites.

It's these carbs that result in prolonged blood glucose levels with glycosylation of protein and lipids over time and the resultant damage to all major systems.

Activated, HIV - infected cells have altered cell - surface glycosylation patterns with respect to resting, uninfected cells.

When we consume too much sugar, it can attach to collagen in the body, disrupting its normal functioning (known as glycosylation) 3.

Glycomine will use the proceeds from this financing to complete IND enabling pre-clinical studies and initiate clinical studies of its substrate replacement therapy in patients with Congenital Disorder of Glycosylation Type Ia (CDG - Ia), and to accelerate discovery efforts towards an enzyme replacement therapy for N - glycanase deficiency (Ngly1).

Additionally, FPs that encode N - glycosylation consensus sequences are modified with the addition of N - glycans [9].

Research published in the Journal of Biological Chemistry shows that a rare type of glycosylation affects the function of an important protein for human development and cancer progression.

To ensure the results are applicable to research on NGLY1, the Mights helped connect the Scripps team with glycosylation expert Hudson Freeze.

For example, about 40 percent of the hormone erythropoietin has to be discarded during manufacturing because of inappropriate glycosylation.

That study showed a change in a pre-membrane protein could cause microcephaly; the Nebraska study showed how glycosylation of the envelope protein may contribute to the virus efficiently gaining entry into the brain.

The structure of Zika virus is similar to other known flavivirus structures, except for the ~ 10 amino acids that surround the Asn154 glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell.

The research team headed by Schwab investigated the biochemical principles of terpene glycosylation.

d. Nanoparticle with adhered synthetic or bacterially developed enzymes to degrade «junk» e. Same things with enzymes that remove known pathological glycosylation.

Many of the resident proteins within these compartments undergo significant post-translational modifications including glycosylation, disulfide bond formation, and proteolytic cleavage.

Jos Jansen and colleagues present an exome sequencing analysis in a family with siblings affected by abnormal Golgi glycosylation.

After glycosylation, pro-collagen is eventually formed which is / are basically chains that are linked with the help of sulfur.

Cancer cells have systematically incomplete glycosylation, including deficient galactosylation of terminal beta - N - acetyl - D - glucosamine residues.

A recent report in Nature Medicine found that a specific glycosylation defect may commonly underly Type 2 diabetes.

A further benefit of acemannan is that when it breaks down in the intestine to the monosaccharide mannose, glycosylation occurs which allows these mannose sugars to attach to proteins or lipids.

As mentioned earlier in our Impact of Cooking, Storage, and Processing section, proteins and amino acids can react with certain types of sugars to produce advanced glycosylation end - products (AGEs) and other compounds (including acrylamides).

Promotes proper nitrogen balance in the body & prevent glycosylation, the combining of a sugar and protein molecule accelerated by elevated bloodsugar.

(Hemomglobin A1C is a form of the key protein in our red blood cells — hemoglobin — in which the protein gets linked up with a sugar molecule through a process called glycosylation.

Clusterin is predicted to appear as a thicker band between 35 — 39 kDa owing to differential glycosylation.

At this point, the hormone insulin steps in to remove glucose from the bloodstream as too much sugar can lead to a dangerous condition known as glycosylation.

Furthermore, we used cutting - edge glycomics technologies to demonstrate that host glycan - lectin interactions and altered host glycosylation are associated with deficits in immune function that in turn contribute to HIV persistence.

In the early 1980s, we discovered that the textbooks were all wrong about protein glycosylation by finding that many proteins within the nucleus and cytoplasm are indeed glycosylated.

To prevent the inappropriate addition of glycans, which are absent from Plasmodium proteins [31], all potential N - linked glycosylation sites (N - X - S / T, where X is not proline) were systematically mutated by substituting alanine for serine / threonine at these sites.

HIV - 1 Env gp120 C2V5 Potential N - Linked Glycosylation Site (s)(PNGs) Variations and Amino Acid Length Polymorphisms among Infected Family Members