It goes on to say that Western diets are low in B1 and high in sugar, which could result in high levels of
glyoxals in the body.
«By simply adding an aqueous solution
of glyoxal to an aqueous solution of hydroxylamine heated to 95 o C, followed by stirring for 3 days, DAG is produced in a much improved 80 % yield.
It contains water, the fizzy antiseptic hydrogen peroxide, and a common, yellowish chemical
called glyoxal.
Scientists traditionally synthesize DAG by reacting a mixture of hydroxylamine hydrochloride and sodium hydroxide with an aqueous solution of the
dialdehyde glyoxal at 95?.
Persistent hyperglycemia in diabetes mellitus results in an accumulation of a series of reactive α - dicarbonyl compounds (α - DCs,
e.g. glyoxal / GO, methylglyoxal / MGO, 3 - deoxyglucosone / 3DG) and α - DC - derived metabolites, called advanced glycation end products (AGEs).
In addition, the work offers insights into nucleation reactions
involving glyoxal in the air.
Summary: Many of the steps are known in
using glyoxal with hydrogen peroxide to form dicarboxylic acids and chains of hydrocarbons, known as oligomers.
Tippelt, S., Ma, C., Witt, M., Bierbaum, S. and Funk, R.H. Collagen type I
prevents glyoxal - induced apoptosis in osteoblastic cells cultured on titanium alloy.
An unavoidable byproduct of this process is the creation of toxic compounds
called glyoxals, which can damage cells and cause disease.
This study offers insights into how chemical building blocks —
glyoxal, water, and hydrogen peroxide — chain together, or nucleate, to form materials.
Reber, F., Geffarth, R., Kasper, M., Reichenbach, A., Schleicher, E. D., Siegner, A. and Funk, R.H. Graded sensitiveness of the various retinal neuron populations on
the glyoxal - mediated formation of advanced glycation end products and ways of protection.
An article in Biochemical Society Transactions reported that B1 (thiamine) helps break down
glyoxals.