Sentences with phrase «goblet cells»
Goblet cells refer to a type of cells found in our body, particularly in our respiratory and digestive systems. These cells, shaped like a goblet or a cup, produce mucus, which helps to protect and lubricate the lining of our organs. Full definition
Resistant starch also prevented loss of goblet cells in the intestinal crypts and TNF - alpha expression in the cecum and increased T - reg cells in the brain by 10-fold.
resistantstarchresearch.com
This was very efficient at reducing lung inflammation and production of mucous - generating goblet cells in our tests.»
Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.
The study noted that the mice eating higher - fat «had an increased number of goblet cells... [and] an increased MUC2 production.»
Along with intestinal stem cells, the team identified differentiated nutrient - digesting and absorbing enterocytes, mucus - producing Goblet cells, hormone - secreting enteroendocrine cells, and microbiome - regulating and sensing Paneth cells, and they performed a series of assays that confirmed their functions.
Goblet cells secrete the principal constituents of mucus.
Infection with human rhinovirus, the most common cause of asthma exacerbation in adults and children, was restricted to ciliated cells and resulted in ciliated cell apical sloughing and goblet cell hyperplasia, replicating hallmarks of cytopathology observed in vivo.
Evans PM, Lynch GL, Labelle P. Effects of oral administration of diphenhydramine on pupil diameter, intraocular pressure, tear production, tear film quality, conjunctival goblet cell density, and corneal sensitivity of clinically normal adult dogs.
It causes intestinal hyper - motility and extremely rapid gut transit time, with partially digested food reaching the large bowel and the associated overproduction of gelatinous mucus from goblet cells of the gut lining (an innate protective mechanism in the gut).
FOXM1 also prevented IL - 13 from causing goblet cell expansion in mice that were given the pro-inflammatory molecule intra-nasally.
KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract
The villi are covered with absorptive enterocyte cells, along with goblet cells that produce mucus, which provide an additional layer of protection — and a potential barrier to the absorption of drugs taken orally.
Healthy individuals» lungs contain very few goblet cells, but patients who die from asthma — an estimated 5,000 people annually — have significantly higher numbers of these cells.
Unlike the type I cervix, whose mucus comes from glands in its crypts, type I rectum is lubricated by goblet cells.
The role of calcium in mucin packaging within goblet cells.
Nevertheless, certain histologic features of chronic bronchial disease are characteristic and include goblet cell hypertrophy and hyperplasia, mononuclear cell infiltration, and increased connective tissue within the lamina propria.
They show that RMC - 1 treatment prevents overproduction of mucous - generating goblet cells in the lungs of mice with asthma and in human airway cell cultures.
«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»
Therapeutic agents able to directly affect gene regulatory networks that trigger inflammation and mucous - producing goblet cells would potentially be more efficient at slowing or stopping disease progression.
lls and resulted in ciliated cell apical sloughing and goblet cell hyperplasia, replicating hallmarks of cytopathology observed in vivo.
Additional therapeutic effects may be achieved via CsA and tacrolimus» anti-inflammatory effects, stimulatory effect on lacrimal glands, proliferative effect on mucin - producing conjunctival goblet cells, and inhibitory effect on lacrimal cell apoptosis.
The scientists searched specifically for compounds that would target FOXM1 and inhibit its activation of downstream pro-inflammatory molecules that drive overproduction of mucous - generating goblet cells.
A goblet cell is a type of secretory cell found in the epithelium of the respiratory, intestinal (scattered among the absorptive cells of the small intestine and colon), and reproductive tracts.
In goblet cell metaplasia, exposure to allergens such as pollen, mold and dust mites initiates a series of biochemical reactions that causes the cells that line the air passages of the lungs to change from their normal state into so - called «goblet cells,» which produce substantial amounts of excess mucus.
All of the cell types in the gut — enterocytes, goblet cells, enteroendocrine cells and Paneth cells — are derived from a type of stem cell that resides within the intestine.
Within the data, the team pinpointed expression signatures specific to known cell types (e.g., enterocytes, goblet cells, Paneth cells, tuft cells), specific cell subtypes or populations (e.g., enterocytes at different stages of maturation), and rare cell types (e.g., M cells).
These range from those that are very similar to the acid - secreting glands of the stomach to those that look like intestinal crypts — indeed intestinalisation (defined by the presence of mucin secreting goblet cells), is diagnostic for Barrett's in some countries.
The cycle begins again... Excessive mucus (along with the cells that secrete mucus — goblet cells) may also be produced as the body tries to protect itself.