The daughter's gonads were also examined after surgery and exhibited an early form of
gonadal cancer.
Even worse, the tissue defects in the original patient identified with this mutation also contribute to the development of
gonadal cancer.
Not exact matches
For some
cancers of interest, not only may breeds vary in predisposition but also the possibility of interactions between gender,
gonadal hormone influences, and timing of
gonadal hormone alteration should be taken into account in selecting the model and in investigating causal factors to be explored.
Comparisons of
cancers in the two breeds suggest that the occurrence of
cancers in female Golden Retrievers is a reflection of particular vulnerability to
gonadal hormone removal.
The relatively high occurrence of one or more of these
cancers in intact male Goldens, coupled with the relative absence of an effect of neutering, except with regard to LSA, points to a relatively high underlying rate of
cancer occurrence in this gender and breed that is not affected by
gonadal hormone removal.
This may reflect a particular sensitivity of receptor sites of some potentially metastatic
cancer cells to
gonadal hormone removal and / or prolonged levels of the gonadotropin hormone, follicle stimulating hormone [28].
The striking effect of neutering in female Golden Retrievers compared to male and female Labradors, and male Golden Retrievers, suggests that for this gender and breed the presence of
gonadal hormones has a protective effect against
cancers over most years of the dog's life.