These subgroups included two biologically distinct groups representing the extremes of
gonadal hormone exposure (i.e., dogs neutered before skeletal maturation at < 1 year of age and dogs that remained sexually intact for their entire lifetime).
We analyzed risk for bone sarcoma using months of
gonadal hormone exposure as a continuous variable.
To determine whether there was an association between endogenous sex hormones and risk of bone sarcoma, relative risk (RR) of incidence rates and hazard ratios for bone sarcoma were calculated for dogs subdivided on the basis of lifetime
gonadal hormone exposure.
To characterize the dose - response relationship between endogenous sex hormones and bone sarcoma risk, a study providing information on lifetime
gonadal hormone exposure would be required.
The possible mechanisms by which
gonadal hormone exposure might protect against the development of bone sarcoma in both males and females are not immediately evident.
For females,
the gonadal hormone exposure subgroups were: spayed before 1 year of age; spayed between 1 and 5 years of age; spayed after 5 years of age; and sexually intact.
Because the database used in that study provided no information on age at gonadectomy, the study could not evaluate bone sarcoma risk in terms of duration of
gonadal hormone exposure.
Lifetime
gonadal hormone exposure of each dog was expressed in terms of total months of
gonadal hormone exposure (i.e., number of months sexually intact).
Not exact matches
Prenatal Testosterone
Exposure Leads to
Gonadal Hormone - Dependent Hyperinsulinemia and
Gonadal Hormone - Independent Glucose Intolerance in Adult Male Rat Offspring.
Behavioural risks in male dogs with minimal lifetime
exposure to
gonadal hormones may complicate
However, in that study, age at neutering was not available, and thus, duration of
exposure to
gonadal hormones for each dog could not be determined.
McGreevy PD, Wilson B, Starling MJ, Serpell JA (2018) Behavioural risks in male dogs with minimal lifetime
exposure to
gonadal hormones may complicate population - control benefits of desexing.