We conclude that the subset of Rottweiler dogs that undergo early
gonadectomy represent a unique, highly accessible target population to further study the gene: environment interactions that determine bone sarcoma risk and to test whether interventions can inhibit the spontaneous development of bone sarcoma.
Among all cancer diagnoses, bone sarcoma was overrepresented in the early
gonadectomy subgroup,
representing 27 of 45 (60 %) cancer diagnoses compared with the sexually intact group in which only 15 of 66 (23 %) cancer diagnoses were bone sarcoma.