Sentences with phrase «good animal models in»

«We have lots of good animal models in the laboratory that we can study.

Not exact matches

[104] In place of WS, animal protectionists hold up their work with sheep producers of Marin County, California as a better coyote management model.

Their dinosaurs and animal models are by far the best I have come across in my almost 10 years of being a parent.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

The CDC team's work combines «superb conventional epidemiology with a well - characterized animal model,» epidemiologists Barry Bloom and Peter Small write in an accompanying editorial.

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

The animals engage in more natural play behavior, Carlos says, and are better models for psychiatric disorders because they're not unnaturally depressed or anxious.

Stress can affect a wide range of physiologies and behaviors, and researchers are beginning to test whether the additions make the animals better models for depression — and, in the case of these particular fish — retinal regeneration.

As noted by Dr. Vicki Ellingrod — the Chair of this session, «Current state - of - the - art research in both animal models as well as humans point to the link between the gut microbiota and mood and anxiety models, as well as the potential for psychiatric medications to directly affect the gut microbiome.»

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

Schmidt says, «These people can test compounds or antibodies in well - defined animal models that are representative of a human disease.»

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

The research showed that moral decisions in the con?ned scope of unavoidable traffic collisions can be explained well, and modeled, by a single value - of - life for every human, animal, or inanimate object.

«There hasn't been a good animal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behanimal model for any kind of speech disorder,» says study author Wan - chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal BehAnimal Behavior.

In the past, researchers assumed that a «Markovian» model best explained the vocal sequences in animal callIn the past, researchers assumed that a «Markovian» model best explained the vocal sequences in animal callin animal calls.

CDNF has shown strong neuroprotective and even restorative properties in animal models of Parkinson's disease as well as spinal and peripheral nerve injuries.

Mead believes ALS is ripe for AI and machine - learning because of the rapid expansion in genetic information about the condition and the fact there are good test - tube and animal models to evaluate drug candidates.

They directly injected into the cerebrospinal fluid of a mouse model of Alzheimer's — adult animals in which plaques were well established — viral vectors carrying genes for one of the three APOE variants or a control protein.

Wild H5N1 viruses can not latch on tothe cells in a person's nose and throat, but the mutant strains created by Fouchier and Kawaoka can spread between ferrets, which are viewed as a good animal model of flu transmission between humans.

In order to gain a better understanding of this process, the researchers used an animal model, which allowed them to interfere with the lipid metabolism, and to knock out the gene responsible for the relevant enzyme, adipose triglyceride lipase (ATGL).

Early treatments in animal models in vivo with hotter lasers didn't work as well.

Significantly, disabling both anti-apoptotic proteins, Bcl - 2 and Bcl - xL, in conjunction with Mcl - 1, caused profound cell death of leukemia cells in the test tube as well as in animal models of AML.

«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.

DNA vaccines have been studied in animal models of viral, bacterial, and parasitic disease, as well as animal models of tumors.

Stories on how making lab animals happy may make them better experimental models, and the chemistry that's happening in the air and on surfaces in our homes

The BUSM researchers believe the data from this study and those reported by others in animal models as well in clinical studies strongly suggest that Avodart may have serious adverse side effects that were not obvious several years ago.

In the end, three companies formed to try to exploit CRISPR to create novel medicines, while Broad and two other companies licensed the technology to partners that hoped to engineer everything from improved crops and livestock to better animal models and industrial chemicals.

The loss was bad for the vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg - grown vaccine did not effectively kill the circulating sugar - adorned viruses.

Serotonin [5 - hydroxytryptamine, (5 - HT)-RSB- function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies.

Major recent advances in understanding GVHD's underlying biology, improved animal models, better targeting of interventions, and more systematic clinical trials are finally moving beyond «accumulated sketchy information,» Pavletic says.

The next step will be to demonstrate efficacy in larger animal models, as well as test whether this approach can be used to protect against or treat other diseases.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

In contrast to previous animal models of NMO that generally produced disseminated lesions, the new localized model has a single well - demarcated inflammatory lesion, allowing precise investigation of the correlation between the lesion with the deficit in motor function disrupting the corticospinal tracIn contrast to previous animal models of NMO that generally produced disseminated lesions, the new localized model has a single well - demarcated inflammatory lesion, allowing precise investigation of the correlation between the lesion with the deficit in motor function disrupting the corticospinal tracin motor function disrupting the corticospinal tract.

Brendan Wintle at the University of Melbourne, Australia, has developed an alternative model that includes data on previous searches in remote regions, as well as aspects of the animal's biology and behaviour.

The project began in 2009 when Krasnow, frustrated by the lack of a good animal model for lung disease — his area of expertise — commissioned three high school interns to search the animal world for something better.

The new NIH project includes collaborators with expertise in animal modeling as well as device manufacturing.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Studying these symptoms earlier in the animal model gives researchers more time to monitor the progression of the disease as well as assess the efficacy of potential therapeutics and to determine if and when the course of the disease could be altered.

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves» disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

Using human and animal models, these studies may help explain why position in social hierarchies strongly influences decision - making, motivation, and altruism, as well as physical and mental health.

In various talks, interviews and articles, he suggested that a mathematical brain model would deliver such fundamental breakthroughs as simulation - driven drug discovery, the replacement of certain kinds of animal experiments and a better understanding of disorders such as Alzheimer's.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaging.

Understanding cattle movement patterns as well as the connectivity of the various sectors of the U.S. cattle industry and incorporating these in the models would allow USDA Animal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including boviAnimal Plant Health Inspection Service (APHIS) Veterinary Services (VS) to develop more effective regulations and control strategies for various animal diseases, including bovianimal diseases, including bovine TB.

Now, researchers at Harvard and Massachusetts General Hospital (MGH) and their colleagues have shown that amyloid - β can protect against yeast and bacterial infections in two animal models, as well as in cultured human cells.

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.