This team aims to increase the understanding of chronic pain mechanisms, help to develop novel analgesics, and develop
better biomarkers for pain.
The principal measure of efficacy is called Area Under the Curve (AUC), a measure of
how well biomarkers identify true cases of disease (sensitivity) while avoiding false positives (specificity).
«A real problem in the field has been
assigning good biomarkers, which would help to treat cancer patients with these pharmacological inhibitors, such as rapamycin.
And closely related to that need is the need for
better biomarkers which can improve the measures of risk, the diagnosis, the progression, and importantly, as we will come to by the end of the talk, serve as an important opportunity to speed clinical trials of therapeutic candidates.
How well the biomarkers would work among people who have not been diagnosed with a psychiatric disease is not known.
The analysis of these changes can be
a good biomarker for water quality.
«If we could incorporate these changes into a wireless EEG test, we could combine all this information and develop
a better biomarker.
«What we need is
a better biomarker that not only tells us that the patient has cancer but what the behavior of that cancer is likely to be,» Garnick continues.
Currently,
the best biomarkers available are measured with neuroimaging or cerebrospinal fluid, which are more difficult and expensive to obtain than a blood test.
«It is always rewarding to find something that might be helpful for a particular disease, but in this case, it is even more relevant since it could also be
a good biomarker to facilitate MSA diagnosis,» agree the researchers.
But it's going to be much easier to test more of them and really learn which ones are going to work, which ones are going to help patients, once we have
better biomarkers — better ways of measuring the progression in this disease.
For these reasons, the HD community is in search of
good biomarkers, tests that can be easily measured to predict disease development and response to treatment.
The partnership and support from Helmsley will allow us to define the most effective approach to forming a Crohn's Disease Biomarker Consortium to take forward
the best biomarkers into regulatory qualification,» said John - Michael Sauer, PhD, C - Path Biomarker Program Officer.
If we had
good biomarkers, we could use them to help determine whether a new drug was having a beneficial effect in a future HD drug trial.
A similar study measured how much vitamin C subjects had in their bloodstreams, as vitamin C level was considered
a good biomarker of plant food intake (and hence was used as a proxy for a healthy diet).
For example, for gluten sensitivity, anti-gliadin antibodies can be
good biomarkers.
DHEA serves as
a good biomarker for androgen production.
While the theory makes sense,
any good biomarker worth its predictive value will also have the following characteristics: