Sentences with phrase «good cell lines»

While this is a step forward, it is unclear if cell lines developed from these embryos, some of which were not used due to concerns over their status, would actually be good cell lines.

Not exact matches

The majority of study participants reported that it's all good, fine and kosher with them (well, technically «generally OK») to use a cell phone when walking down the street, riding public transit and waiting in line.

Because your gut is often the first entry point for pathogens, you'll want to ensure that you have enough friendly gut flora (the good bugs that are allies for immune cells) to prevent pathogens and infections from being absorbed through the gut lining.

I know there are lots of you looking for a good homebirth story to come here, but the «story» could more be summed up in a three - line haiku, should the proper brain cells of mine be in order to actually write one (they're not, I assure you.

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

Lomita's best line — bipartisanship in Albany means Democratic former Assembly speaker Sheldon Silver and Republican ex-Senate majority leader Dean Skelos could share the same jail cell — was the laugh riot of the night.

«Didn't seem to have a good response to the question about his previous experience with our cell line.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

Today's version of the NPS1 model includes a digital simulation of every building in the area affected by the bomb, as well as every road, power line, hospital, and even cell tower.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

And to study many developmental disorders, such as fragile X syndrome, researchers would be well served to be able to study a stem cell line that contained the relevant mutations.

In this study, rather than studying one iPS cell line, the researchers derived and sequenced 10 iPS cell clones from each patient tissue sample to get a better understanding of mitochondrial DNA mutation rates.

She sees all these lines of research converging on the notion that a strong cell - mediated response gives people the best chance of defeating HIV.

The study builds on previous findings suggesting that AIM2 limits cancer cell growth in colon cancer cell lines, Wilson said, as well as on a clinical report of poor prognosis in colon cancer patients with low or missing AIM2 levels.

Given their similar profiles, Seyedsayamdost and coworkers hypothesized that TDA might exhibit anticancer properties as well, and indeed observed its strong anticancer activity in a screen against 60 different cancer cell lines.

Furthermore, they have found that neural stems cells can be culled from the patient's bone marrow, thus circumventing ethical and political obstacles to neural stem cell therapy as well as problems with immune rejection that sometimes arise when researchers must employ embryonic stem cell lines.

The researchers showed that cabazitaxel worked better than docetaxel in human prostate cancer cells lines that were resistant hormone treatment, both in terms of slowing cancer - cell growth and in its ability to kill cancer cells.

However, these poisons can also do significant harm to other dividing cells such as those found in the stomach lining and in hair and nail follicles, as well as the blood and immune stem cells in the bone marrow.

To put the combinatorial screen with the CLOUD to the test, Kubicek's group investigated the effect of pairwise combinations of CLOUD compounds on the viability on KBM7 leukemia cells, a cell line well suited for drug experiments.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

The solutions include better validation of tissue samples and cell lines.

The research, the team said, should not discourage the pursuit of experimental treatments but instead be heeded as a call to screen rigorously all cell lines for mutations at various stages of development as well as immediately before transplantation.

He also inserted the disease - causing variation into one healthy cell line from a family member, as well as the cell line from the unrelated control.

The study used a well - known line of pancreatic cancer cells (AsPC - 1) in the laboratory and assessed how well this grew when treated with either the chemotherapy drug gemcitabine or different levels of commercially available chokeberry extract alone, and when treated with a combination of gemcitabine and chokeberry extract.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

When Sukumar and the others depleted the HOXA5 protein in other breast cell lines in the lab, the cells became more immature, or «stem like,» as well as more mobile.

Among other effects, immune cells disrupt the function of the endothelial layer, the lining of the blood vessels, counteracting «all the good things that the endothelial cells produce,» says physiologist Brett Mitchell of Texas A&M College of Medicine in College Station.

Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.

Three weeks after the scientific world marked the 20th anniversary of the birth of Dolly the sheep new research, published by The University of Nottingham, in the academic journal Nature Communications has shown that four clones derived from the same cell line — genomic copies of Dolly — reached their 8th birthdays in good health.

The current study just looked at cells of the epithelium, the layer of cells lining the gut, but there would be other cells responding to these microbial signals as well.

Instead, they show the expression of certain genes and DNA methylations were better indicators of the efficiency at which a cell line could be differentiated into the hematopoietic lineage.

Melton says the protocol seems to work equally well with ES and iPS cell lines.

Although the transferred nucleus isn't adequately reprogrammed to make an animal, it can be tested to see if it functions well enough to make a line of stem cells.

The only stem cell research he would permit, Bush said, was research using existing embryonic lines as well as so - called adult stem cells, which occur in anyone of any age.

Hwang later admitted faking data to make the papers look better but claimed that a colleague duped him into thinking that the cell lines were genuine.

«If there are 60 cell lines, that's news to me — and good news,» says cell biologist Douglas Melton of Harvard University, who has been working with both animal and human ES cells.

In principle, tissue banks of parthenogenetic cell lines could include enough different immune protein combinations to treat up to half of the U.S. population — men as well as women — Lanza says.

Since last year, teams in Italy, Scotland, and the United States have reported deriving ES cell lines from human parthenotes, although none of the lines is well studied.

As famously chronicled in science writer Rebecca Skloot's best - selling book, the cell line was established, without Lacks's consent, from a cervical tumor that she was diagnosed with in 1951.

This study utilized 36 well - characterized melanoma cell lines assembled by the MGH Center for Molecular Therapeutics to test all possible combinations of more than 100 oncology drugs, two - thirds of which are currently in clinical use.

More than 5,775 potential drug combinations, as well as each single drug, were screened against each cell line, looking for effects on the number and viability of tumor cells.

Endothelial cells (passage 5) from each line were plated onto 96 - well plates at a density of 1000 cells / well in 10 % DMEM.

A549 (human lung adenocarcinoma) and BSC - 1 (African green monkey kidney epithelial) cell lines as well as PMK (primary rhesus monkey kidney) cells are routinely maintained at the Viral and Rickettsial Disease Laboratory (VRDL) branch of the California Department of Public Health.

«What ReNeuron has done to create this cell line is ambitious and well thought out,» adds neurologist Sean Savitz of Harvard Medical School.

First, a hair follicle contains epithelial cells — a cell type that lines the body's vessels and cavities — as well as a specific kind of adult stem cell called dermal papillae.

We are studying these proteins in the intestine and liver in vivo, as well as in epithelial cell lines.

During the next five years, KOMP2 will transform the knockout mouse embryonic stem (ES) cells into adult mice for 2,500 lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.

These lines would allow scientists to better study conditions ranging from diabetes to Parkinson's disease, and they would provide the basis for potential patient - specific stem cell treatments.

By pairing engineered cell lines containing disease - specific mutations with high throughput screening, we can investigate the role of given mutations in the biology of disease as well as identify potential druggable targets.

The authors studied a standard panel of 60 established human tumor cell lines representing nine different human cancers, as well as several specimens of human primary ovarian cancer.