Sentences with phrase «good clinical trial design»

The ECCO - AACR - EORTC - ESMO Workshop on Methods in Clinical Cancer Research is an educational programme that introduces junior clinical oncologists in any oncology subspecialty to the principles of good clinical trial design.

Not exact matches

«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

It will house 150 researchers and clinician scientists, as well as an additional 100 people working in clinical trial design and administration.

She says a number of experimental drugs now in clinical trials are designed to target serotonin in other ways in the brain, and may have better success than the SSRIs.

The next step, says Salem, will be to try to correlate these findings with patient treatment outcomes, initially as a retrospective, or backward looking study, and then hopefully design a forward looking clinical trial to determine which treatments may be best for patients with SBAs.

«This will require discussions about alternative approaches to the design and conduct of clinical trials as well as to how interventions are approved by the Food and Drug Administration.»

Toxicologist Thomas Hartung of the Johns Hopkins Bloomberg School of Public Health in Baltimore agrees: «Clinical drug trials in general are very well designed.

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.

His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials.

But he says their findings may have more immediate implications as well, for the design of clinical trials evaluating the benefits of providing nutrients to patients with sepsis.

The discovery will also help researchers design clinical trials and pick the patients who have the best chance to respond to the therapy.

In just the last 6 years the EID outbreaks of MERS, Ebola, Zika, CHIKV as examples have underscored the importance of rapid vaccine development and deployment capabilities to meet EID challenges, as well as growing appreciation for creativity and flexibility in clinical trial design.

When conducting clinical trials, Rutgers Cancer Institute of New Jersey's most important responsibility is to protect patients through well - designed protocols, a dedicated Institutional Review Board (IRB), a careful informed consent process and rigorous monitoring of the safety of the clinical trial.

«As a national leader in designing, conducting and analyzing all phases of clinical trials, the University of Chicago is well positioned to play a leadership role in the new network,» said Michelle Le Beau, PhD, Arthur and Marian Edelstein Professor of Medicine and Director of the University of Chicago Medicine Comprehensive Cancer Center.

But, he notes that it will be necessary to perform well - designed clinical trials that test the safety and efficacy of high - grade NMN in humans before making the leap to using NMN (or perhaps its analogs) as pharmacotherapeutic agents.

In the next several years, when the laboratory process for recreating micro tumors is fast and reliable, Dr. Simeone expects to offer a Phase 1 clinical trial to design tailored single and combination therapies, as well as experimental agents targeting specific mutations.

The BabySeq Project: Genomic Sequencing for Childhood Risk and Newborn Illness (U19 HD077671) is a first - of - its - kind randomized clinical trial designed to examine how best to use genomics in clinical pediatric medicine by creating and safely testing methods for integrating sequencing into the care of newborns.

Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study design.

I can also spot poor experimental and clinical trial design and methodologically flawed studies — and I know that the evidence for cause and effect in humans is incredibly tenuous at best.

Several well - designed clinical trials have examined the use of fish oil on nonsteroidal anti-inflammatory drug (NSAIDS) use or steroid use in non-surgical back pain and rheumatoid arthritis.

We're also requiring makers of testosterone products that are authorized to run a well - designed clinical trial to address the question of whether an increasedd danger of stroke or heart attack exists among users of thes items.

All clinical trial protocols are reviewed by two separate review boards to ensure that the studies are well - designed, risks are mitigated and there is a reasonable likelihood of a similar or better outcome compared to current standards of veterinary care.

Researchers at the UCLA Stroke Center in Los Angeles identified 13 well - designed clinical trials of folic acid and stroke.

With a strong background in clinical research (immunoassay development, protein extraction and purification, molecular and cell biology and pharmacology), in combination with medical and scientific writing as well as working experience with regulatory affairs and clinical trial planning and designing, my education and experience can bring a solid foundation to the ar...

Well conducted analogue studies can inform the design of subsequent clinical trials and may indicate if treatment methods are acceptable to clients, and practicable to deliver by therapists.

An attractive feature of this well designed clinical trial was the testing of «allegiance effects» by conducting the study at 2 sites, each associated primarily with publishing outcome studies of either psychosocial or pharmacological treatments.

Several elements of this important, well designed, clinical trial by Maude - Griffin et al are noteworthy from a clinical perspective.

The IHDP began in 1985 and was designed as a eight - site, randomized clinical trial evaluating early childhood development, center - based education, and home - based family support services, as well as pediatric surveillance in an attempt to reduce the risk for developmental delay, behavioral issues and health problems LBW, PT (≤ 37 weeks gestational age) infants.