Sentences with phrase «good early clinical»

An advisory panel to the FDA recommended approval of Provenge on the basis of good early clinical results, but the FDA instead requested more information last May after a second phase III clinical trial seemed more equivocal.

Not exact matches

Through talking to experts in the field over the past year, Gates said he had identified five areas of need: Understanding better how Alzheimer's unfolds, detecting and diagnosing it earlier, pursuing multiple approaches to trying to halt the disease, making it easier for people to take part in clinical trials of potential new medicines, and using data better.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Lacazette has showed early signs of his pace to get in behind opposition defences, as well as his clinical finishing, as he scored both goals in Arsenal's most recent victory at the Emirates Stadium.

Toss in his 57 % shooting accuracy, 14 % chance conversion rate, and an early season goal to better see the youngster's clinical nature in the final third.

Substantive research already exists showing nut free schools (not early childhood, but mid elementary onwards) actually do more harm than good, to the extent that the official anaphylaxis prevention guidelines have been updated by the Australasian Society of Clinical Immunology and Allergy to explicitly state that food bans in upper primary and high schools do not work, and can actually cause problems.

Your baby steadily gains weight Whilst nothing can prepare you for the early arrival of your baby and the alien, clinical environment in which you have to spend the early days, we hope this small guide offers you a little help in giving your precious child the best start you can offer.

Whilst nothing can prepare you for the early arrival of your baby and the alien, clinical environment in which you have to spend the early days, we hope this small guide offers you a little insight & help in giving your precious child the best start you can offer.

Low family income during the early childhood has been linked to comparatively less secure attachment, 4 higher levels of negative moods and inattention, 5 as well as lower levels of prosocial behaviour in children.2 The link between low family income and young children's problem behaviour has been replicated across several datasets with different outcome measures, including parental reports of externalizing and internalizing behaviours,1 - 3, 7 -9,11-12 teacher reports of preschool behavioural problems, 10 and assessments of children based on clinical diagnostic interviews.7

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Notwithstanding his superlative boast earlier this year, Governor Andrew Cuomo on Friday described his relationships with New York City Mayor Bill de Blasio in almost clinical terms, offering all - is - well claims that belie the current frostiness between the Democratic politicians.

But a blood test could help researchers more easily identify people who might be good candidates for clinical trials of early interventions, says Steven Kiddle, a biostatistician at the University of Cambridge, who wasn't part of either study.

It could also identify those patients with early signs of autoimmunity who might be good candidates for clinical research studies.

What little encouraging Alzheimer's treatment data does exist — including that around a promising drug called aducanumab — suggests medications that have gone through clinical trials seem to work better earlier in the dementia disease course, before patients develop full - blown Alzheimer's.

A key component of our early development engine is our planned 200,000 square foot Good Manufacturing Practices (GMP) mRNA clinical manufacturing facility in Norwood, Mass..

«The clinical implications of our findings are that early introduction of allergenic foods (egg, cow's milk products, and peanut) before age one should be encouraged and is better than food avoidance for reducing the risk of food sensitization,» said Mr. Tran.

«The good news is that this finding predicts that patients missing either gene should be sensitive to new therapies targeting focal adhesion enzymes, which are currently being tested in early - stage clinical trials,» says Shaw, who is also a member of the Moores Cancer Center and an adjunct professor at the University of California, San Diego.

Despite lowering low - density lipoprotein (LDL), known as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

«There is a tremendous unmet clinical need for better non-invasive screening tools for early detection of prostate cancer to reduce the overtreatment and morbidity of this disease,» added Dr. Patel.

The clinical trial will help to determine if the early microbubble intervention results in overall better outcomes for patients.

In a presentation of early clinical trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists from the University of New Mexico Comprehensive Cancer Center reported that a large number of study participants responded well to the drug combination.

The researchers hope their confirmation of the earlier study may help lead to better clinical care of patients who may be at high risk of this fatal condition.

«To preserve patient access to this treatment option, and given the scale that we've reached, demonstrating the safety and efficacy of fecal transplantation through adequate and well - controlled clinical trials is the right thing to do,» explained Carolyn Edelstein, OpenBiome's director of Outreach and Public Affairs, in an op - ed published earlier today with the Fecal Transplant Foundation.

Both hospital units work jointly since 1995 to offer diagnosis and assessment services in families with hereditary cancer, as well as clinical monitoring, prevention, early detection and highly specialised treatments for patients.

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

One of the early pioneers of angiogenesis research, Dr. Konerding leads a group focusing on angiogenesis in inflammation, wound healing, and tumor growth, as well as on clinical anatomy.

So far, JQ1 has been relatively well tolerated in both preclinical studies and in early phase clinical trials for cancer patients.

Dr. Best has a special interest in training and supervising clinical staff, students, and early career psychologists in the effective delivery of CBT to...

This recommendation was rooted in an earlier observation by Williams et al, 19 based on both priority scores and funding rates, that clinical grant applications do not fare as well in the review process when evaluated by study sections reviewing relatively few clinical applications.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

I am developing mathematical and statistical tools to disentangle tumor cell population structure, enabling an earlier and more accurate diagnosis of the disease and better - informed clinical decisions.

People in the early stages of dementia may be able to enroll in clinical trials, as well, to gain access to experimental new treatments.

Because Hashimoto's is a progressive disease that can be treated and reversed, especially when identified in early stages, prior to the clinical diagnosis as an autoimmune disease, it is important to seek proper testing and diagnosis from a practitioner well - versed in the disease.

Show Notes: [1:36]-- nourish balance thrive podcast [4:44]-- Overcast podcast app [5:48]-- Chris the pro mountain biker [9:54]-- How Chris began in FM [16:10]-- The value of using a copywriter [19:32]-- How Chris meet Dr. Tommy Wood [23:00]-- Clinical Concierge Coaching [24:30]-- Kalish Institute, Functional Nutrition Diagnostics, metabolic fitness pro by Brian Walsh [29:00]-- What Chris learned from doing over 1000 free consultations [35:50]-- Some mistakes Chris made early on [38:44]-- Iron overload [43:50]-- The trap of overtraining, and how to help people get better without reducing exercise [48:42]-- The beauty of working with athletes [50:18]-- The software that Chris uses for tracking functional medicine blood chemistry — Blood Chemistry Software [53:44]-- Chris's software he created to extrapolate the raw data from Ubiome [59:22]-- Thoughts on Blastocystis by Christen Rune Stensvold [1:03:54]-- Chris's experience with Nutritional Ketosis [1:09:12]-- Tim Ferris interview with Patrick Arnold, Peter Attia [1:16:18]-- Organic Acid Testing — Byran Walsh Metabolic Fitness Pro and the Khan Academy

The Dementia Strikes Children Too campaign aims to raise awareness of childhood dementia, drive for better clinical education of this group of diseases, and put in place the systems and tools for earlier diagnosis.

Circulating testosterone levels decline with increasing age but do not appear to be significantly affected by the menopausal transition.8 As early as the 1940s, testosterone was reported not only to alleviate menopausal symptoms but also to restore libido.9 In recent years, evidence has accumulated supporting the hypothesis that the decline in endogenous testosterone levels is associated with menopausal symptoms, including decreased libido, worse moods, and poorer quality of life.10 Clinical trials have demonstrated that exogenous androgens in conjunction with estrogens can ameliorate symptoms affecting sexual function and general well - being.11, 12 In addition, studies have found beneficial effects of androgen therapy on bone mineral density.13 - 15

The «Train the Trainer» prospectus offers schools the opportunity to train their own teachers to be able to deliver some of the early intervention programmes, as well as providing those teachers with the resources to train others within the school to identify and develop support for specific mental health issues and signpost those needing clinical intervention.

In recognition of the need for more and especially better clinical preparation, researchers are now arguing for a shift away from the typical student teaching experience as a distinct and final step in completing preparation and toward integrating clinical components into the preparation experience early and throughout the program.30 A number of programs across the country have made this shift, including by incorporating residency models into their teacher preparation programs, 31 but this kind of program design is still relatively uncommon.

The press release quotes the Vice Chairman, Richard Mulligan, Ph.D, as saying «While we may evaluate PEG - SN38 in earlier lines of colorectal cancer treatment in future clinical trials, at this time, resources associated with such trials are better directed toward areas of study with nearer - term commercial potential.»

We can not promise any benefits to your horse or other animals from your taking part in this clinical trial; however, possible benefits include lowering the incidence of this common eye cancer in Haflinger, Belgian, Percheron, Appaloosa, and Arabian Horses, helping breeders to make informed mating decisions, and better prediction of the risk of developing disease for earlier diagnosis and treatment.

Prevention of Strangles includes good herd health management, cleanliness, early detection of clinical signs, and quarantine of affected horses.

Good clinical results (i.e. your dog will not be painful) are usually seen if treatment starts early, before osteoarthritis (degenerative changes in the joint) has developed.

Prognosis depends on the cause of the heart disease, but early diagnosis with regular check ups at the vet and keeping an eye out for clinical signs at home, will give your dog the best chance at the longest happiest life.

Detection can be very difficult, especially early in the course of disease when clinical signs are absent or subtle at best.

In my opinion, the very best approach to managing this condition is with an integrative protocol instituted at the earliest onset of clinical signs.

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Clinical research coordinators are well trained people who are required to participate in the early planning phases of clinical Clinical research coordinators are well trained people who are required to participate in the early planning phases of clinical clinical studies.

Joella currently co-facilitates IOP groups in early recovery skills, relapse prevention, family education, and mindfulness - based relapse prevention; as well as providing clinical, client care coordination, and administrative support for the IOP program.

Her full time clinical practice focuses on the long term impact of attachment disorders and early life trauma, as well as dissociation, anxiety, depression, and relationship problems.