Fruit flies serve as
a good model organism for understanding the molecular mechanisms behind many human diseases — around 75 percent of disease - causing genes are found in the species in a similar form.
For Polly and Lawing, rattlesnakes make
a good model organism for tracking how species respond to climate change.
And the organism is an even
better model organism than we could have hoped for.»
The Avian Model Systems meeting is a unique conference of scientists striving to make birds
the best model organisms possible for many avenues of research.
Not exact matches
Scientists need a
better model than the clock, and we believe that they can find this in the
organism.
Birch and Cobb maintain that the ecological
model is more adequate than the mechanical
model for explaining DNA, the cell, other biological subject matter (as
well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure at each level (of an
organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).
It «just screamed that it would be an example that would fit really
well with this
model organism approach.»
The stick insect is a popular
model organism in biological research for gaining a
better understanding of insect walking movements.
But the few predictive
models are still hotly debated, and they apply to only a narrow range of
organisms at
best.
Species distribution or crop - niche
modeling is another sophisticated technology that archeologists use to predict where plants and other
organisms grew
well in the past and where they might be useful today.
But geneticists chose Arabidopsis as their
model organism based on its relative genetic simplicity, as
well as its short generation time.
He also believes the technique will work reasonably
well for studying the structure and function of proteins in most other
model organisms, including laboratory mice.
Furthermore, climate
models for every ecosystem need to
better account for
organisms such as termites and mussels that «engineer their own environment,» Huisman said.
«It is not a
good genetic
model organism, but it does regenerate — and that makes it an awesome biological
model,» says David Gardiner, a developmental biologist at the University of California, Irvine, who has studied axolotl regeneration for decades.
The assay we present here provides a perfect
model to begin to fill these gaps and should lead to a
better understanding of host - pathogen interactions in the complex setting of a multicellular
organism.
«The fruit fly is a
well - known
model organism used to understand human biology as it, like all other living
organisms, has to fend off various viral infections.
In addition, the significant number (> 1000) novel
models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even
well - studied
model organisms.
As our role in the HapMap concluded, we took on a new grant: constructing the genetic map of C. briggsae, a small roundworm similar to the
well - known
model organism, C. elegans.
The zebrafish is a
good choice because of its similarity to humans as a vertebrate, its transparency as an embryo, and the powerful genetic tools available in this
model organism.
The
model organism offers a way to
better understand stem cell - driven regeneration processes, an important step in regenerative medicine and the promise of therapies to repair or replace damaged human tissue.
There, she has established the worm C. elegans as a novel
model organism to examine the cellular transformations involved during a direct reprogramming event in vivo, as
well as the genetic cascade involved.
Many researchers assumed the
organism was too simple to serve as a
good model when studying the complexities of neurodegenerative diseases.
To facilitate the search, I utilize discoveries and insights from various fields, including evolution, functional genomics, natural (dog) and artificial (mouse)
model organisms as
well as cell
models.
Physiological based pharmacokinetic
models (PBPK) have been incorporated into food web
models to
better predict tissue levels and effects on the individual
organism.
These tools will help to
better understand ongoing changes in chemical and biological state of the North Sea from alkalinity fluxes originating from the Wadden Sea over a synthesis
model that integrates OA sensitivities at
organism level into a North Sea ecosystem
model (5.1) to an economical impact assessment.
This will require bringing together the functional experts (molecular biology,
model organisms, and reverse genetics) with the «gene hunters» as
well as a serious commitment from funding agencies.
The zebrafish comes close to being the ideal
model organism for vertebrate development because it appears to combine the
best features of all the other
models.
Importantly, some freely - available resources that link
model organism genes to human diseases will be presented to promote a
better understanding of the mammalian genome.
Furthermore, none of the currently available gene - finders has a universal Hidden Markov
Model (HMM) that can perform gene prediction for all
organisms equally
well in an automatic fashion.
Our lab investigates the mechanisms by which this complex and similar groups of proteins organize DNA and regulate transcription in human cells and tissues, as
well as in the
model organism of Drosophila melanogaster.
The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a
model organism to study cell, developmental and nervous system biology, as
well as human aging and diabetes.
Our group is using in vitro and vivo
models to help study various pathogenic
organisms to
better understand the risk that they pose to the blood supply and to help develop vaccine and therapeutic options.
The most
well - studied species on the planet are called
model organisms, creatures chosen for intensive research because they are particularly suited to laboratory studies.
Model organisms are not restricted to mammalian
models, and they include genetically modified or mutant
organisms and embryos, as
well as relevant protocols and genetic and phenotypic data for mutant strains.
The Core also provides access to diverse invertebrate and non-mammalian vertebrates, including local marine
organisms as
well as experimental
models such as Xenopus laevis.
To
better serve the broader research community, WormBase, with five other
Model Organism Databases and The Gene Ontology project, have begun to collaborate formally as the Alliance of Genome Resources.
Deletion of the TAM from a naive strain of E. coli results in a drastic time delay in folding of UshC, which can be observed for a protein from EPEC as
well as for two introduced proteins from related
organisms, Yersinia and Enterobacter We suggest that this
models why the TAM machinery is essential for efficient folding of proteins acquired via lateral gene transfer.
Unique research resources include synthetic compounds,
model organisms, cell lines, viruses, cell products, and cloned DNA, as
well as DNA sequences, mapping information, crystallographic coordinates, and spectroscopic data.
The synapse between a neuron and a muscle — the neuromuscular junction — of a fruit fly larva turns out to be a
good model for studying how the nervous system works in general, which can be applied to other
organisms, including humans.