Sentences with phrase «good vaccine candidates»

Not exact matches

«The candidate vaccine prompted a robust immunological response in recipients and was very well tolerated,» noted VRC scientist Julie E. Ledgerwood, D.O., principal investigator of the trial.

With a better understanding of how the networks of the body's immune system respond to the disease, researchers could be more selective in the vaccine candidates that they invest time and money in developing.

This candidate vaccine was delivered without an adjuvant — a substance added to vaccines to improve the immune response — but still prompted a good response, said Dr. Ledgerwood.

The mice described in the current report were developed for testing of drug and vaccine candidates and may not be good models for human transmission, said Weaver.

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

In WP10, iBET will be involved in activities relating to GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, as well as the evaluation of development, manufacturing and finishing documentation.

Metabolomic profiling of vaccine candidates by SB measurement (LU): LU will analyse metabolic pathways based on samples from the above tasks and will extend the analyses to other project samples as well.

NIBSC has a well - established, dedicated biological facility and relevant models for evaluating the protective potencies of BCG and new TB vaccine candidates.

The Fraunhofer IME leads the Transnational Access 1 (TNA1) «Cross platform screening and optimization service «and the corresponding Joint Research Activity (JRA1) «Improved optimization and harmonization of cross-vector screening «both aiming at the provision of comprehensive range of different well established pro- and eukaryotic expression / production systems to identify the optimal manufacturing platform for any given vaccine candidate.

Systems biology research will aim to identify and validate mathematical models that can accurately predict interactions between immune system components in relation to vaccination, as well as develop state - of - the - art methods for the structural and functional analysis of vaccine candidates.

W. Bogers: PhD in immunology and 20 years of experience with NHP models for the preclinical evaluation of HIV vaccine candidates as well as testing antivirals.

In WP10, iBET will be involved in the GMP - directed evaluation of vaccine candidate production processes, production scale - up for vaccine candidates, definition of specifications for pilot - scale production, product stability testing and delivery for GLP toxicology studies, as well as the evaluation of development, manufacturing and finishing documentation.

In April 2017, Moderna published human data for its mRNA vaccine technology in Molecular Therapy, which showed that its first prophylactic vaccine candidate, mRNA - 1440 — an mRNA prophylactic vaccine against avian H10N8 influenza — induced high levels of immunogenicity and was safe and well tolerated.

The P27A vaccine candidate has a good safety profile, no serious adverse events were observed and the most frequent adverse event was pain at the injection site.

They selected the combinations of backbone mutations that supported better growth in cell culture, identifying two candidate backbones that led to higher amounts of vaccine virus.

His work centers on new immunomodulatory agents and formulations, as well as the process development necessary to take vaccines and therapeutic candidates from the lab to the clinic.

In order to move forward they made pioneering technological breakthroughs as well, all of which have resulted in the most promising vaccine candidate against malaria to date.

That makes these molecules good candidates for a vaccine without unintended consequences.

Here we report the use of a liposomal vaccine for the generation of a monoclonal antibody with particular characteristics that makes it a valuable tool for fundamental studies as well as a candidate antibody for diagnostic and therapeutic applications.

A good knowledge of correlates of protection could predict the efficacy of novel vaccines at early stages of development and help identify the most promising candidates for vaccine trials.

Lease Amendment I secured space to support the production of its recombinant anthrax vaccine candidate as well as its other programs.