Sentences with phrase «good vaccine response»

Chemotherapy and steroids suppress the immune system and deplete its ability to produce a good vaccine response.

Khatri thinks the new study will lead to more research into how these genes encourage a good vaccine response.

The list for your baby includes improved immunity and respiratory health associated with a 50 % SIDS reduction, fewer allergies, asthma, and ear infections, a better vaccine response, and reduction of chronic diseases like Crohn's and Diabetes.

Not exact matches

A new study shows pregnant women who get flu shots regularly have a weaker peak antibody response to the vaccine than women who don't get them regularly, though mothers and their babies in both groups were well - protected at the time of delivery.

«The emergence of Zika virus has further complicated vaccine design, and emphasizes the need to better understand the molecular mechanisms that underpin protective antibody responses.»

Essentially, he's looking for immune cells with barcodes that proliferate in individuals with a good response, as opposed to those in whom the vaccine is ineffective.

Understanding the body's immune response to a given vaccine could help make better and more effective vaccines in the future.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

«The candidate vaccine prompted a robust immunological response in recipients and was very well tolerated,» noted VRC scientist Julie E. Ledgerwood, D.O., principal investigator of the trial.

Vaccines block virus entry by making good use of such responses.

«If it does interfere with our immune response, it could become a target for vaccine development, not only for Zika virus, but possibly other viruses as well.

This candidate vaccine was delivered without an adjuvant — a substance added to vaccines to improve the immune response — but still prompted a good response, said Dr. Ledgerwood.

«An RSV vaccine with this M2 - 2 deletion could tip the balance toward a better immune response, which is what we predicted based on earlier laboratory studies,» says study leader Ruth A. Karron, MD, director of the Center for Immunization Research and a professor in the Department of International Health at the Bloomberg School.

The CDC schedule for childhood vaccinations, which relies on recommendations from the Advisory Committee on Immunization Practices and is endorsed by the AAP, is drawn up based on data detailing when the body's immune system will mount the best response to the vaccine and, second, balanced against the need to protect kids at the earliest age possible.

The vaccine generated a pool of TH1 CD4 + T cells (also called helper T cells) that are necessary for an effective antibody response as well as a stable pool of CD8 + T memory cells.

The best immune response was shown in a group of nine test persons who received the highest dose of the vaccine three times at four - week intervals.

«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.

«We learned in this study that grabbing hold of these glycans can be a very important early step in an effective immune response to HIV, and with this knowledge, we believe we can design better candidate vaccines,» said principal investigator Dennis R. Burton, professor of immunology and microbiology at TSRI.

The study, published in the Journal of Infectious Diseases and funded by vaccine - maker Sanofi Pasteur, found that — with the exception of one strain of flu circulating in the 2012 - 2013 season — the high dose flu vaccine helped participants mount a better immune response to influenza than the standard flu shot.

Systems biology provides better methods of drug discovery: research teams can measure changes in genetic activity, protein levels and cellular behavior of the immune system in response to a potential vaccine.

For 30 years, researchers have struggled to determine which immune responses best foil HIV, information that has guided the design of AIDS vaccines and other prevention approaches.

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

Some individuals may be better suited than others to work in high - risk job placements during an infectious disease outbreak because they are more likely to have an adequate response to a vaccine, or because their genotype is associated with a lower risk of developing severe infection.

Vaccinating older individuals is problematic, as the effectiveness of most vaccines decrease with age, with maximal responses often as low as 30 % in the over 70s.5 Nevertheless, vaccination programmes demonstrate the ability to reduce disease burden in the elderly as well as offering a tool to observe immune responses in vivo in humans.

It is critical to understand how best to design a cancer vaccine such that it recognizes only the tumor without inducing an equally destructive autoimmune response to normal issue.

An analysis of HIV vaccine trials (mostly ones that use DNA vaccines) showed that women showed better T - cell responses to such vaccines than men, and people with a lower body mass index showed better T - cell responses than people with a higher body mass index.

The first Phase 1 study of this vaccine in a malaria - exposed population found it to have promising safety and tolerability profiles in adults in Bandiagara, Mali, and to elicit dose - dependent anti-AMA1 antibody responses [17] as well as IL - 5 production and lymphocyte proliferative responses [22].

One of the best studied examples of maternal Ab impact on infant immune response is the measles vaccine.

The focus of this application is to develop an adenovirus - based vaccine against rabies virus that can provide rapid immunity following a single administration to achieve prophylactic status and as well as in response to a bioterrorism attack.

«Paradoxically, the study does offer some good news for those working on live vaccines or live vaccine vectors because these are not just vaccine antigens but organisms in their own right that necessarily manipulate host responses (such as those involving IL28B) for their own survival.

Thus, discovery of the immune responses and progression of pathogenesis, as well as eventual countermeasure impact by the delivered drug / vaccine, can be greatly aided by live cellular and animal imaging.

After identifying these genes, the team used another 82 blood samples to double - check that the genes predicted a good response to the flu vaccine.

To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.

Although these vaccines produce good antibody responses, a large part of the population still wasn't protected from each of the serotypes.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

Rather than using a killed or attenuated virus to develop a vaccine for dengue, de Silva's lab is focusing on «expressing the E protein and attaching it to nanoparticles to induce good immune responses,» Metz said.

«Given separately and concurrently, both vaccines were safe, well - tolerated, and elicited antigen - specific humoral and cellular immune responses.»

Dr. Julie Overbaugh studies the infant immune response to HIV — which could provide clues to building a better vaccine.

«Successful vaccines all mimic the body's natural immune response and this just does not work well in HIV - infected people.

Using gene - targeted mice and human cells that lack specific components of the immune system, a better understanding of the immune response to DENV and ZIKV is critical for developing much - needed vaccines and antivirals.

People who had a better antibody response to the vaccine after 28 days had higher levels of HLA - DR (a cell surface protein which is a marker for immune stimulation) on a specialised type of dendritic cell.

A healthy gut and good nutrition are important for a healthy immune system and a good immune response to vaccination, so it is not surprising that vaccines have been found to be less efficient in malnourished children.

In fact the presence of good humoral antibody levels blocks the anamnestic response to vaccine boosters just as maternal antibody blocks the response in some young animals.»

There is also concern that the quality of the immune response to Chlamydia vaccines is not as good as that for FHV - 1 and FCV.

Live attenuated influenza vaccines have been shown to provide better immune responses to protect against influenza.

Single vaccine administration also reduces the likelihood of adverse events as well as increasing the animal's immune response.

Mike Kohn, DVM: «In response to this [vaccine] violation, there have been increased autoimmune diseases (allergies being one component), epilepsy, neoplasia [tumours], as well as behavioural problems in small animals.»

It is important your horse has proper time to process vaccines and mount a good immune response, so consider vaccinating at least 30 days prior to traveling.

It has been shown that healthy pets will have a good, protective immune response to the administered vaccine when given at this age.

As a result, our pets» bodies can have appropriate vaccine response symptoms as well as unexpected