Dr. McCleary - Wheeler's research interests focus on uncovering the molecular mechanisms driving cancer development and progression through detailed investigations into the regulatory mechanisms
governing gene expression.
Not exact matches
Last December, the same research team demonstrated blocking the
expression of the
gene that encodes apoC - III led to major relief of triglyceridemia in patients suffering a rare and extreme form of hypertriglyceridemia, which in turn opened the door for the identification of unexpected mechanisms that
govern blood fat.
The behaviour of all living matter is
governed by
gene expression, the process by which biological materials such as proteins are made.
Today, the question has been taken up by cognitive scientists who want to link facial
expressions to emotions in order to track the
genes, chemicals, and neural pathways that
govern emotion in the brain.
Myc is a critical
gene in
governing cell proliferation and survival, activities that it carries out by regulating the
expression of other
genes involved in cell metabolism.
Professor Dermitzakis» research focuses on the genetic basis of regulatory variation and
gene expression variation in the human genome, the processes that
govern non-coding DNA evolution.
The World Anti-Doping Agency (WADA), whose drug code
governs the Olympics and other events, defines
gene doping as «the non-therapeutic use of cells,
genes, genetic elements, or the modulation of
gene expression, having the capacity to enhance athletic performance» [source: WADA].
The MYC protein acts as a transcription factor that
governs the
expression of many important
genes.
Others were unanticipated, including significant differences in
expression levels among
genes involved in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch - signaling — part of a complex system of communication that
governs basic cellular activities and coordinates cell actions.
By determining how changes in
gene expression affect the fate of glial cells in mice, we hope to understand the key factors that
govern neural cell regeneration in the human brain.
Dr. Loftus» research is aimed at understanding how the human genome regulates
gene expression, with a focus on how this controls the cellular processes
governing mammalian development.
Ultimately, increasing our knowledge of how genomic
gene expression is
governed will contribute to our ability to predict both an individual's inherent disease risks and their potential to respond to therapeutic interventions when diseases arise.