Spinal muscular atrophy involves wasting of the skeletal muscles and is caused by
gradual degeneration of nerve cells in the spinal cord.
Intervertebral disks can become displaced, deteriorate, collapse, bulge out (protrude), rupture or herniate in dogs as a result of
gradual degeneration due to conformational abnormalities, obesity, genetics, repetitive trauma or other factors.
Gradual degeneration of the mitral valve is an inherited condition in many old and young King Charles Cavalier Spaniels.
PRCD causes
the gradual degeneration of the rods and cones, the sensory cells lining the back of the eye.
Progressive retinal atrophy (PRA) is a group of eye diseases featuring
the gradual degeneration of the retina.
Unique to the canine stifle, cranial cruciate ligament disease appears to involve
a gradual degeneration and destruction of the ligament itself.
[68][69] Mechanical stress, oxidative damage and inflammatory mediators combine to induce
the gradual degeneration of the articular cartilage in the joint, resulting in reduced muscle mass, pain, and locomotion.
This is often the result of
the gradual degeneration of the tissues that make up the ends of long bones such as those in the hips, legs, and even digits.
PRA is
a gradual degeneration of the retinal tissue.