Sentences with phrase «grafted stem»

«We showed that 3K3A - APC helps the grafted stem cells convert into neurons and make structural and functional connections with the host's nervous system,» Zlokovic said in a university news release.

Dr Vassilis Koliatsos, from Johns Hopkins Medical Institutions, who worked on the study, said: «We were extremely surprised to see that the grafted stem cells were not negatively affected by the degenerating cells around them, as many feared introducing healthy cells into a diseased environment would only kill them.

Earlier work has shown that grafted stem cells reprogrammed to become neurons can, in fact, form new, functional circuits across an injury site, with the treated animals experiencing some restored ability to move affected limbs.

Not exact matches

The researchers also found that arteries and veins from the macaques» hearts grew into the new heart tissue, the first time it has been shown that blood vessels from a host animal will grow into and nurture a large stem - cell derived graft of this type.

This image shows an implanted graft of cardiac cells derived from human stem cells (green) meshed and beat with primates» heart cells (red).

The recipients did not suffer from the many common adverse effects of stem transplants, including the grueling graft - versus - host disease, which can cause severe liver damage, rashes, diarrhea and even death.

The treatment — a whole - body graft of genetically modified stem cells — is the most ambitious attempt yet to treat a severe form of epidermolysis bullosa (EB), an often - fatal group of conditions that cause skin to blister and tear off at the slightest touch.

Two approaches to fat grafting — injection of fat cells versus fat - derived stem cells — have similar effects in reversing the cellular - level signs of aging skin, reports a study in the April issue of Plastic and Reconstructive Surgery ®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

But stem cell biologist and physician Michele De Luca of the University of Modena and Reggio Emilia in Italy and his colleagues have been developing a way to counteract an EB - causing mutation by inserting a new gene into the cells used for grafts.

«Given the serious threat of graft - versus - host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need,» said Dr. Leslie Kean, the trial's principal investigator and associate director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's.

«To have a therapy at our disposal that safely targets just the T cells causing graft - versus - host disease would represent a major step forward in stem cell transplantation.

«Immunotherapy drug nearly eliminates severe acute graft - versus - host disease: Drug used to treat rheumatoid arthritis improves survival after hematopoietic stem cell transplant.»

A study published in Cell last year demonstrated that human and rat stem cells could be grafted onto the spinal cord of paralyzed rats, forming new nerves capable of communicating across the injury site.

Researchers from Japan's RIKEN institute announced in April that they have grown skin from mouse stem cells in a process that one day may help skin graft recipients.

«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»

Hütter speculates that Brown was helped to a total cure by what is known as the host - versus - graft reaction: New stem cells and all their progeny see the old immune cells as «other» and kill them off.

One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.

A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.

Graft - versus - host disease is a condition in which the patient's immune system is attacked by the donor stem cells.

Wartman has a chronic form of graft - versus - host disease (GVHD), a debilitating consequence of blood stem cell transplants.

A new study in rats shows that lacing a penis graft with adult stem cells yields better healing and sexual function than using the graft alone.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

The team seeded pig intestine grafts with adult stem cells taken from fat tissue in rats.

The results, published online today in the Proceedings of the National Academy of Sciences, suggest that lacing the grafts with stem cells enhances blood flow and boosts the production of molecules that make and maintain erections, all of which makes for a better penis reconstruction.

Cells from the penises with stem cell - laced grafts contained more neuronal and endothelial NOS, enzymes that help trigger and maintain erections.

Adding adult stem cells (inset) to penis grafts improves healing and sexual function in rats.

Grapes are commonly grafted, so the root system is genetically different from the top portion that produces the stems, leaves and fruit, referred to as the scion, explained Fennell.

A stem cell - derived neuron grafted onto a mouse cochlea in the inner ear that lacked neurons.

Studies have shown that the clinical success of transplantation depends on the number and percentage of limbal stem cells in tissue grafts.

It has taken more than five years of graft, but at long last approval has been given for the first clinical trial using human embryonic stem cells (hESCs).

Currently, PBSCs are the major stem cell source, owing to faster engraftment and ease of collection despite a higher rate of graft - vs - host disease and lower survival rates in patients with nonmalignant disorders.

Mice with human astrocytes performed better on memory experiments than those that had received mouse cell grafts, the team reports today in Cell Stem Cell.

Lead researcher Dr Gordana Vunjak - Novakovic said: «The availability of personalised bone grafts engineered from the patient's own stem cells would revolutionise the way we currently treat these defects.»

A Phase III Randomized Open - Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid - Refractory Chronic Graft vs Host Disease after Allogenic Stem Cell Transplantation (REACH 3)

As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation.

Sorting stem cells before transplant helps lower the risk of graft - vs.

Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.

The only documented long - term complete remissions reported in multiple myeloma patients have occurred with allogeneic bone marrow transplantation, where a donor's blood stem cells (graft) are transplanted into the patient (host) with multiple myeloma.

The first group of stories is related to adult stem cells (although this is not explicitly stated or explained): the discovery of stem cells during WWII, the amazing rescue of two boys in the early 1980s using stem cell - based skin grafts, and the present - day treatment of blind patients in a stem cell clinic in India.

Human - Induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke - damaged brain.

For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.

Vianello F, Dazzi F. Mesenchymal stem cells for graft - versus - host disease: a double edged sword?

But for blood cancer patients who receive donor hematopoietic stem cell transplants as part of their treatment, graft - versus - host disease (GVHD) often hampers their recovery.

Sorting stem cells before transplant helps lower risk of graft - vs.

Functional integration of grafted neural stem cell - derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model

The new immune system that grows from the donor stem cells can recognize myeloma cells as «foreign» and kill them, which is known as the «graft - vs - myeloma» effect.

Abbreviations: AD - MSC: adipose tissue derived mesenchymal stem cells; APC: antigen presenting cell; BM: bone marrow; CNI: calcineurin inhibitor; DC: dendritic cells; GVHD: graft - versus - host disease; HLA: histocompatibility locus antigen; HGF: hepatocyte growth factor; IL: interleukin; IDO: indoleamine 2,3 - dioxygenase; MLR: mixed lymphocyte reaction; MSC: mesenchymal stem cells; PGE2: prostaglandin E2; SC: stem cells; TGF: transforming growth factor; TH: T - helper; T - regs: T - regulatory cells.

We have observed significantly better graft and patient survival in stem cell group vs. controls with additional benefits of minimization of immunosuppression.

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.

Dr Astrid Limb's expertise focuses on investigations into overcoming natural barriers for retinal stem cell transplantation, to create a permissive environment in which grafted cells could functionally integrate.