Sentences with word «granulocyte»

Recombinant human granulocyte colony stimulating factor for treatment of puppies with neutropenia secondary to canine parvovirus infection.

There are three different forms of granulocytes: basophils, eosinophils, and neutrophils.

Suspecting that the two events were related, Stromnes looked and discovered that the tumors were indeed attracting these Gr - MDSCs by releasing a protein called granulocyte macrophage colony - stimulating factor (GM - CSF).

Acute myeloid leukemia (AML) is characterized by a rapidly - developing cancer in the myeloid line of blood cells, which is responsible for producing red blood cells, platelets and several types of white blood cells called granulocytes.

Growth factor therapy with granulocyte colony stimulating factor (G - CSF)-- to stimulate the bone marrow to make more white blood cells

Eosinophils, like all other granulocyte forms, destroy parasites.

As compared with control mice, Del - 1 − / − mice displayed enhanced disruption of the blood — brain barrier and increased infiltration of neutrophil granulocytes in the spinal cord in the course of EAE, accompanied by elevated levels of inflammatory cytokines, including interleukin - 17 (IL - 17).

It merely demonstrates that caffeinated coffee causes a rise in blood levels of a growth factor known as granulocyte colony stimulating factor (GCSF), which is significantly reduced in individuals with Alzheimer's and shown to improve memory in mice with Alzheimer's.

Several of the viruses also release the gene for granulocyte - macrophage colony - stimulating factor (GM - CSF) an immune system protein.

This is due to a randomised trial with 215 eligible patients performed between 1989 and 1991, which showed a significant increase in severe thrombocytopenia, severe anemia, pulmonary complications and toxic deaths when granulocyte - macrophage CSFs (GM - CSFs) were used during concurrent chemo - radiotherapy.

The most striking abnormalities were a markedly elevated white blood cell count of 28,500 per cubic milliliter (the normal level is about 5,000 to 10,000) and what is called a shift to the left, which refers to a large increase in the number of mature and immature granulocytes, cells that increase in number when an acute infection must be fought off.

Out of 1,368 granulocyte transfers at least 34 percent reached the blastocyst stage, and two actually resulted in living pups (who did not survive for long), according to the paper presenting the result published online in Nature Genetics on October 1.

The MGH - based team conducted an RNA - interference - based genome - scale screen of mouse macrophages, selectively knocking down the expression of around 8,000 genes, and found that TREML4 — one of a family of receptors found on granulocytes and monocytes — amplifies the response of innate immune cells to activation via TLR7.

Jäger E, Ringhoffer M, Dienes HP, Arand M, Karbach J, Jäger D, Ilsemann C, Hagedorn M, Oesch F, Knuth A. Granulocyte - macrophage - colony - stimulating factor enhances immune responses to melanoma - associated peptides in vivo.

Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte - macrophage colony - stimulating factor - secreting breast tumor vaccine: a chemotherapy dose - ranging study of safety and immune activation.

Human Granulocyte monocyte colony growth factor produced in E.coli and purified via sequential chromatography.

Neutrophils are the most common granulocyte cell type found in the blood system.

For this reason, granulocytes contain big granules packed with enzymes that help to digest the foreign molecule.

Il3 alone does not support granulocyte / macrophage colony formation in bone marrow cells from A / J mice but does in bone marrow from C57BL / 6 controls; costimulation with both Il3 and SCF increases the number of colonies formed compared to SCF alone

Primary overall survival from OPTiM, a randomized phase III trial of talimogene laherparepvec (T - VEC) versus subcutaneous granulocyte - macrophage colony - stimulating factor (GM - CSF) for the treatment of unresected stage IIIB / C and IV melanoma.

Granulocyte dysfunctin or adhesion defect: an impairment of neutrophil function or adhesion which causes chronic recurring infections, stunted growth and secondary increase in immune globulins (hypergammaglobulinemia).

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

A team of researchers at Ligand Pharmaceuticals in San Diego and SmithKline Beecham Pharmaceuticals in Collegeville and King of Prussia, Pennsylvania, wanted to find a mimic of granulocyte - colony - stimulating factor (G - CSF), which is commonly used to boost patients» immune systems after chemotherapy.

Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

Maharaj and the experts consulted by STAT said that, to their knowledge, Maharaj's trial will be the first to try a new twist on young blood infusions: injecting the young donors with a drug called granulocyte - colony stimulating factor, or G - CSF.

The system is based on the Appendicitis Inflammatory Response (AIR) score, which includes the following parameters: pain in right iliac fossa, history of vomiting, rebound tenderness or muscular guarding, body temperature, white blood cell count, proportion of neutrophil granulocytes, and C - reactive protein concentration.

Leukemia that starts in myeloid cells — the pathway that leads to red blood cells, platelets (cells that clot the blood), or white blood cells known as granulocytes — is called myeloid (or myelogenous / myeloblastic) leukemia.

While at CSU Dr. Obradovich won two national awards through the Veterinary Cancer Society and the American College of Veterinary Medicine for her research with «granulocyte colony stimulating factor» or G - CSF.

Transforming growth factor (TGF)-- alpha, TGF - beta, and granulocyte colony - stimulating factor (G - CSF) are also identified in human milk.

Granulocyte colony - stimulating factors (G - CSFs) are commonly used as a supportive measure to boost the survival, proliferation and differentiation of neutrophils.

In this process, several hundred times more cells of the so - called myeloid lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T cells, B cells, natural killer cells) do.

Now, a study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM - CSF (Granulocyte macrophage colony - stimulating factor) likely plays an important role in human disease and offers a new explanation for why the MS treatment interferon - Beta (INF - β) is often effective at reducing MS attacks.

In fact, only 4 percent of stem cell transfers produced nascent embryos compared with 8 percent of progenitor cells and 35 percent of granulocytes.

Xiangzhong Yang of the University of Connecticut and Tao Cheng of the University of Pittsburgh as well as a host of colleagues examined the cloning potential of three different types of cells: hematopoietic stem cells, progenitor cells and granulocytes.

Each represents a different stage in the differentiation process of blood cells; stem cells can become any kind of blood cell, progenitor cells are already on a particular track and granulocytes are a specific type of white blood cell (further specified as neutrophils).

Sargramostim is a form of GM - CSF (granulocyte - macrophage colony - stimulating factor), a natural protein that spurs the growth of white blood cells in the immune system.

Added to the mix is a delivery agent, granulocyte - macrophage colony - stimulating factor (GM - CSF), that promotes the production of white blood cells; the vaccinal mix is then injected back into the patient.

They also filled the tablet with GMC - SF (granulocyte macrophage colony - stimulating factor), an inflammatory protein known to attract immune cells.

However, the researchers observed that only 20 to 30 percent of HSCs took on this generalist role, contributing all of the most abundant types of white blood cells — called granulocytes, B cells and T cells.

A decrease of histone Arg methylation, with a concomitant increase of citrullination, requires PAD4 activity in human HL - 60 granulocytes.