Tumors of ovarian stromal cells include
granulosa cell tumors, thecomas and interstitial cell tumors (luteomas).
Stromal
granulosa cell, epithelial tumors and dysgerminomas may become very large, in which case a swollen abdomen is the main sign.
The prolonged heat may also be the result of persistent high level of estrogen provoked by an ovarian cyst or by
a granulosa cell tumor of the ovary.
Hepatocyte growth factor promotes cell proliferation and inhibits progesterone secretion via PKA and MAPK pathways in a human
granulosa cell line.
The Colorado lab discovered that
granulosa cells — the cells that surround maturing eggs in the ovarian follicles — were pumping out leptin and shipping it into the egg.
And with that, he began prying away
the granulosa cells clinging to the eggs, in order to get a better microscopic view of the nascent embryos to see if they were developing properly.
From the time an egg begins to develop in one of a woman's ovaries,
the granulosa cells serve as a communication system — signaling, for example, when the egg needs nutrients and proteins.
If you believe, for example, that
granulosa cells and other very early features of ovarian ecology set up the polarities that ultimately determine the quality of a human egg, as Albertini does, then certain techniques widely used in IVF may be subtly perturbing the very mechanisms that eggs use to establish a plan to build an embryo and maximize the chances that it will develop properly.
These are called
granulosa cells, and under the microscope they look like grapes glued to a beach ball.
A mature egg, ready for fertilization, is covered with clusters of
granulosa cells.
Albertini and his colleagues noticed that the interaction between the oocyte and the cells surrounding it was not symmetrical; there were more cells — and, it would turn out, more molecular back - and - forth traffic between the egg and
the granulosa cells — at certain regions on the egg.
Van Blerkom had been seeing hints of polarity since the 1970s, but one of the major turning points occurred in 1996 when, by accident, his lab discovered that cells surrounding the developing egg — the same
granulosa cells that had piqued Albertini's interest — possessed a receptor very similar to the leptin receptor.
In fact, Albertini has preliminary evidence suggesting that the communication between the egg cell and its surrounding
granulosa cells rises and falls in a precise monthly cycle.
Mycotoxin zearalenone exposure impairs genomic stability of swine follicular
granulosa cells in vitro Xue - Lian Liu, Rui - Ying Wu, Xiao - Feng Sun, Shun - Feng Cheng, Rui - Qian Zhang, Tian - Yu Zhang, Xi - Feng Zhang, Yong Zhao, Wei Shen, Lan Li International Journal of Biological Sciences 2018; 14:294 - 305
FGF2 and its receptors have been shown to be expressed at the protein level by both oocytes and
granulosa cells up to secondary follicles [28], but the expression patterns in antral follicles have not been studied to date.
Berberine improves insulin resistance in
granulosa cells in similar way to metformin.
Expression of ER - alpha mRNA was similar in control and PCOS follicles in
the granulosa cells, but in the theca cells, ER - alpha concentrations were significantly increased in the PCOS samples, compared with the controls.
By the end of the follicular phase, the luteinizing hormone surge results in ejection of the oocyte and transforms the remaining follicle into the corpus luteum; small and large luteal cells are formed from theca and
granulosa cells, respectively.
Once recruited, it takes more than 300 days for a follicle to complete the preantral period, during which time
granulosa cells replicate and theca cells are recruited.
Thyroid hormones work synergistically with follicle - stimulating hormone to develop healthy
granulosa cells.
During the first 2 - week period of the cycle, theca cells produce androgens, and
granulosa cells aromatize androgens to estrogen.
Tola EN, Mungan MT, Uğuz AC, Naziroğlu M. Intracellular Ca2 + and antioxidant values induced positive effect on fertilisation ratio and oocyte quality of
granulosa cells in patients undergoing in vitro fertilisation.
Not exact matches
Thyroid hormones have also been found to augment steroidogenesis from
granulosa and large luteal
cells.2
Some studies have found breeds like Boxers, German Shepherds, Yorkshire Terriers, English Bulldogs to be at an increased risk for
granulosa - theca
cell tumors, a type of sex cord stromal
cell tumor.
These mares can have a tumor on an ovary called a
granulosa theca
cell tumor.