Sentences with phrase «granzyme in»

Lieberman notes that her laboratory reported a similar reaction to perforin, granulysin and granzyme in intracellular bacteria in a 2014 Cell paper.

Not exact matches

Particularly prominent in the RNA - Seq analysis was the up - regulation of a number of granzymes, a group of proteinases secreted by immune cells that were originally thought to be involved in killing (via apoptosis) virus infected cells or other target cells.

They also found elevated granzyme A levels in blood samples taken from non-human primates infected with chikungunya, as well as from human chikungunya patients.

NK cells are cytotoxic; small granules in their cytoplasm contain special proteins such as perforin and proteases known as granzymes.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

Consistent with previously reported analyses, we also observed enhanced IFN - γ and granzyme B production in DGKζ and Cbl - b — deficient T cells.

Further, although we could detect enhancement of granzyme B production in DKO T cells relative to WT, DGKζ − / −, or Cbl - b − / − T cells at early time points (Fig. 3B, upper panels), we did not observe enhanced granzyme B production in DKO relative to DGKζ − / − or Cbl - b − / − T cells at later time points (Fig. 3B, lower panels), at higher or lower concentrations of anti-CD3 Ab, or with addition of anti-CD28 Ab (Supplemental Fig. 2B).

In particular, they investigate how killer immune cells use pore forming protein perforin, antimicrobial peptide granulysin, and immune protease granzyme B in synergy to destroy pathogens in host cellIn particular, they investigate how killer immune cells use pore forming protein perforin, antimicrobial peptide granulysin, and immune protease granzyme B in synergy to destroy pathogens in host cellin synergy to destroy pathogens in host cellin host cells.

First, after culturing human peripheral blood mononuclear cells (hu - PBMCs) with the IL - 15 superagonist, flow cytometry revealed increases in granzyme B and perforin expression in the CD3 -, CD16 +, CD56 + NK cells.