Researchers have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times
greater than the human genome.
Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times
greater than the human genome.
Not exact matches
Studies over the past decade have revealed that the complexity of the
genome, and indeed almost every aspect of
human biology, is far
greater than was previously thought.
When they measured the concentrations in the same area in chimp brains, the team found that the differences between chimps and normal
humans were much
greater for those nine
than for the 12 metabolites not implicated in schizophrenia, suggesting that energy pathways implicated in schizophrenia were also altered by
human evolution, the team reports this week in
Genome Biology.
Cheaper, and more efficient, gene editing technology that allows scientists to manipulate the
human genome with
greater ease and precision
than ever before is forcing researchers to consider these questions quickly.
By contrast, the hundredth most cited article on the
human genome has been cited a few hundred times.The
great majority of the 34,510 papers on the
human genome listed in the Science Citation Index have been cited fewer
than 10 times; ones that were never cited are not even listed.
Although CRISPR is incredibly useful for generating mutations by NHEJ and generating small mutations with HDR, when it comes to larger scale
genome editing, such as replacement of a mouse gene with its
human ortholog (
greater than 5 kb), it remains to be seen whether CRISPR is as robust as conventional gene targeting.
While the
genomes of two
humans may only vary by 0.1 %, two strains of the same bacteria can differ by more
than 50 % —
greater than the disparity between the
genomes of
humans and mice.
«Even though a microbial
genome is one - thousandth the size of the
human genome, the total number of microbial genes in [the
human] body is much
greater than human genes because you have so many different species,» says Weinstock.