To find out, Barr and his colleagues
grew human lung tissue in the lab.
Not exact matches
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Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory -
grown,
human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward
lung cancer development.
To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with
human bronchial cells, which line the airways of the
lungs, and
grew them in a laboratory.
As it can take weeks to
grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the
lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.
Although the organoids don't
grow enough to replicate entire
human organs, these mini-versions can mimic the 3 - D cellular infrastructure of everything from our guts to our
lungs.
In recent years, several groups of scientists have
grown lung cells from
human iPSCs, but the recipes aren't perfect — the resulting
lung cells
grow amidst a jumble of liver cells, intestinal cells, and other tissues.
Now, scientists at Boston University's Center for Regenerative Medicine (CReM) have announced two major findings that further our understanding of this process: the ability to
grow and purify the earliest
lung progenitors that emerge from
human stem cells, and the ability to differentiate these cells into tiny «bronchospheres» that model cystic fibrosis.
By using molecular genetic tools to reduce the amount of PC in
human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to
grow bacteria and other cells), and a reduced rate of tumor growth in mice.
When
growing on surfaces (including
human skin,
lung, heart, or bladder) many bacteria form so - called biofilms that consist of structured communities of identical bacteria.
The researchers grafted breast or
lung tumors in mice, allowed the tumors to
grow to small size and removed these tumors surgically — essentially mimicking the situation in a
human tumor patient in which the tumor is surgically removed as soon as possible after diagnosis.
When
human lung and bladder cells are
grown in the lab, they turn cancerous at a higher rate if exposed to nicotine compounds found in e-cigarettes
The virus, however,
grew efficiently in a
human A549
lung adenocarcinoma cell line.
If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to
grow human hearts,
lungs, livers, and kidneys for transplant but also to model
human diseases more closely than current lab animals do and to test experimental drugs.
One new way that scientists study this process of cellular development — and a way in which they hope to
grow replacement tissue for medical treatments in the future — is by recreating the essential features of
human brains, eyes,
lungs, and guts in a petri dish.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic
lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a
growing charge toward the clinic, with
human clinical trials expected to begin in 2019.
Normal
human lung fibroblasts (NHLF) cells
grown in 384 - well Optilux plates were treated with candidate compounds and incubated for 18 hours prior to fixation and staining with Hoescht dye and anti-HMOX1 antibody as described in Materials and Methods.
In this study,
human lung cancer cells with additional copies of the opioid receptor
grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.
Perhaps the natural landscape creates a
lung for creativity in desolate expanses, providing room to
grow in places where the
human being takes up little space.
The researchers conducted tests by
growing both healthy
human -
lung cells and precancerous
human -
lung cells in laboratory flasks.