Each of these different cell types expresses
different groups of genes at different times over the lifespan of an individual.
It is believed to be controlled by a genetic cluster, or
large group of genes, and ranges in severity from mild impairment to total blindness.
There are some data on
how groups of genes are impacted by one chemical, and other genes are affected by different chemicals.
They found that
groups of genes appear to work together in heart cells in a coordinated fashion — switching on and off as a group at designated times during embryonic development.
Similar to a computer network which increases its computing capabilities by linking several computers together,
groups of genes work together through pathways to enhance cell function.
One suite of genes is active in prostate tumors, for example, while an entirely
different group of genes is turned on in breast cancer.
«It's interesting that we are seeing the same modifications to the same
groups of genes in lineages with large brains - primates, cetaceans, elephants.
In the LOX deficient mice, they observed changes in mechanical behavior and in signaling
of groups of genes that appeared to be a susceptibility differentiator in certain sections of tissue; the way they interacted seemed to provide some protection against aneurysm.
In our ongoing attempts to understand the parts that make up the genome, biologists have linked a particular
group of genes called the major histocompatibility complex (or the MHC group for short) to both our body's ability to protect itself against disease and our sense of sexual attraction.
More than one quarter of children with two copies of a high - risk variant in a
specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5.
This
small group of genes are expressed and functional only from a copy inherited from only from our mother or only from the father, in contrast to the over 20,000 genes expressed from alleles inherited from both parents.
«We have
found groups of genes that may play a role in shaping the development of imbalanced gut microbes.»
So his team sifted through genetic information from 45,000 microbes,
flagging groups of genes with unknown functions that were located near known defense - related genes.
More analysis showed that altering Cdk5 activity changed the level of
several groups of genes that were also affected by aging, including those that control immunity, energy, and antioxidant activity.
Women tended to prefer the odors of men without similar MHC genes, suggesting not only a link between the
MHC group of genes and body odor, but also our preference for MHC genes that differ from our own.
Then there were four
groups of gene carriers: (1) those predicted to develop HD symptoms in a decade or more, (2) those predicted to develop symptoms in a few years, (3) those with early symptoms, and (4) those with more advanced symptoms.
Use of this method loosens the stringency in the analysis,
since groups of genes are examined together allows a significance matrix to be made based on the networks formed [46].
Maniatis and colleagues found that deleting one
group of genes in the cluster didn't cause the axon tangling, leaving two possible suspects.
[This was] followed by rapid change, along the five million years of the human lineage, that was concentrated on these
specific groups of genes.»
«This allows a
large group of genes to be controlled rhythmically within a period of about 24 hours,» Preußner said.
This latest research, published in the journal Cell Reports reveals that when cells start specialising into different cell types their gene activity becomes more «noisy» — each cell starts to turn
different groups of genes on or off.
This is
the group of genes which act as the immune system markers on cells, protecting them from being attacked by the system's anti-bodies.
This is because of something you inherit from your parents:
a grouping of genes that make you more or less sensitive to certain tastes.
McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease,
groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.
Their analyses suggest that underexpression of 10 specific gene sets —
groups of genes that encode the same biological pathway or process — are consistently associated with Parkinson's.
They found that
a group of genes in the nucleus accumbens — an area involved in creating pleasurable feelings — were expressed most strongly in their group of alcoholic smokers (Alcoholism: Clinical and Experimental Research, DOI: 10.1111/j.1530-0277.2010.01207.x).
Starting in 1983, Pereira - Smith and Smith published a series of studies establishing that senescence is a dominant genetic trait involving several as - yet - unknown genes (or
groups of genes): In the simplest scenario, a cell enters cellular limbo only if it carries at least a single normal copy of each of the genes.
His team identified that 18 of 173 people from the community lacked
a group of genes.
As a grad student, I once spent 2 months demonstrating that three particular amino acids on a protein in the arabinose operon (
the group of genes that allows bacteria to metabolize a certain sugar) do not play a role in causing that protein to bind to other copies of itself.
Scientists have identified differences in
a group of genes they say might help explain why some people need a lot more sleep — and others less — than most.
Evolutionary geneticist Liran Carmel of the Hebrew University of Jerusalem and colleagues found that the extinct hominids had lower levels of activity in
a group of genes called the HOXD cluster, which governs limb growth.
Groups of genes that together play a role in the same function were found to change expression in opposing directions.
The analysis revealed that one
group of genes, the group of voltage-gated ion channels, was of particular relevance.
The group of genes of the ion channels correlated strongly with the activity of two brain regions in the cerebrum and the cerebellum.
If getting rid of some of the genes affected the bacteria's ability to fight off phages, that result suggested
the group of genes was a defense system.
«What's cool about
this group of genes is that they also get turned on in human melanoma,» says Zon, who is also a member of the Harvard Stem Cell Institute and a Howard Hughes Medical Institute investigator.
Since the successful sequencing of the human genome, interest in
the group of genes encoding proteins responsible for DNA remodeling has grown exponentially.
Of particular interest was
the group of genes responsible for temperature sensation, which also play roles in hair growth and fat storage.
Agaba first noticed
a group of genes regulating metabolism and growth that were diverged in giraffe as compared to okapi.