Kieny said that for reasons that aren't fully understood, vaccine companies that use eggs to
grow vaccine viruses get yields of only 25 % to 50 % of those obtained during the production of seasonal vaccine.
Not exact matches
Joy: Yeah, but the point is we have the technology now to sequence and manufacture
vaccines fairly quickly; and ideally they wouldn't be
grown in eggs or whatever, right; because what if it starts as a
virus in chickens or something, and we're screwed.
Both
vaccines were based on live, weakened strains of polio
virus grown in monkeys» kidney cells.
At the centre of the theory is the plausible, if unlikely, speculation that a direct forerunner of HIV contaminated monkey cells that were used to
grow polio
virus for the
vaccines.
The company uses cells to
grow the
virus for the
vaccine and claims that this «shows significant time saving» over traditional production with eggs.
The new sugar molecule hinders the
virus's ability to
grow in eggs — so once the
vaccine strains are put into eggs, they ditch it.
Frieden, who called the delays «enormously frustrating,» said manufacturers have difficulty
growing the
viruses used to make
vaccine.
Despite efforts to immunize more girls against HPV with the Gardasil or Cervarix
vaccines — and continued debate about recommending the
vaccine for boys — experts expect that number of these
virus - linked cancers to continue to
grow.
Kirschstein worked on another aspect of
vaccine safety, doing «very prominent» early research on another
virus, simian
virus 40, which contaminated some of the monkey cells used to
grow poliovirus for the Salk
vaccine, says Singer, who later joined the same field.
The loss was bad for the
vaccine: In a series of experiments Hensley and his colleagues showed antibodies from humans and ferrets (a good animal model for influenza A studies) that had been exposed to the egg -
grown vaccine did not effectively kill the circulating sugar - adorned
viruses.
That's bad news: the more
virus a
vaccine requires, the fewer doses that can be
grown in a given time.
He notes that the new study is especially relevant because it worked in mammalian cells, which ultimately are a better way to
grow the
virus than eggs: It's a faster production system and avoids mutations that occur when the
virus adapts to chicken eggs, which can compromise
vaccine effectiveness.
HCV can not be
grown reliably in the laboratory, a failing that has slowed critical studies of everything from drugs to
vaccines to basic knowledge of the
virus's life cycle.
The best strains we have for a H1N1 swine flu
vaccine grow only as half as fast as ordinary
vaccine viruses, meaning poorer nations may not get it in time if there is a second wave
So, due to natural changes in the
virus as it evolves, as well as due to mutations that may be caused by
growing the
vaccine strain, the circulating
virus and the
vaccine become less well matched over time.
«We have solved a fundamental problem that scientists had accepted would be part of
vaccine production — that the
virus is always going to mutate if it is
grown in eggs,» said senior study author Nicholas S. Heaton, Ph.D., assistant professor of molecular genetics and microbiology at Duke University School of Medicine.
The RabAvert ® rabies
vaccine (Chiron Corporation, Emeryville, California, United States) is a sterile freeze - dried
vaccine obtained by
growing the fixed -
virus strain Flury LEP in primary cultures of chicken fibroblasts.
«It is better to produce influenza
viruses for
vaccine production in cells instead of eggs, but the problem is that influenza
virus does not
grow well in cell culture compared with embryonated eggs.»
In human medicine, our
growing knowledge about the role of
viruses as a cause of certain cancers has led to the development of
vaccines as preventives, such as
vaccines against human papillomaviruses, the main cause of cervical cancer in women.
Viruses in
vaccines are
grown on living tissue, and they're often from other species.
This occurs because the
viruses and bacteria used in
vaccines are
grown in cell cultures and nourished with calf serum.
In those later cases, it was often the modified live
virus in the
vaccine itself that
grew and caused the illness.
In human medicine, our
growing knowledge about the role of
viruses as a cause of certain cancers has led to the development of
vaccines as...
The rest of these
vaccines are freeze - dried living
virus that have been
grown in tissue culture in a way that makes them non-pathogenic (weak) i.e. unable to cause disease.