Sentences with phrase «growth factor levels»

Reproducibility of plasma steroid hormones, prolactin, and insulin - like growth factor levels among premenopausal women over a 2 - to 3 - year period

The former may want to preserve body fat and promote fertility and ovulation, while the latter may want to reduce her insulin and growth factor levels, and lose weight in order to promote health longevity.

The research, published in Science Translational Medicine, linked decreased epidermal growth factor levels in urine to worsening kidney disease.

Increased epidermal growth factor levels in human milk of mothers with extremely premature infants.

High serum vascular endothelial growth factor level is an adverse prognostic factor for high - risk diffuse large B - cell lymphoma patients treated with dose - dense chemoimmunotherapy.

Not exact matches

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

It's clear that the growth is due to a confluence of factors: Welch's reputation and brand; a pragmatic education based on Welch's well - known dictums; the relatively low $ 39,000 price of the program (Indiana University's Kelley Direct program costs $ 66,000, while the University of North Carolina's MBA@UNC is priced at $ 99,700); and high levels of student satisfaction.

Demand for our offerings may fluctuate based on numerous factors, including the spending levels and growth of our current and prospective support subscription customers, and general economic conditions.

Any feedback into prices is dampened by the low level of wage growth, rebalancing of factor shares, and a relatively low correlation that has developed over time re the price - wage relationship.

When we factor growth in, the numbers all begin to blend together, making all of the FAANG stocks valued at the same levels.

But consumption patterns are likely to diverge from past cycles, given long - term factors inhibiting wage growth, still elevated debt levels and an older population.

Structural factors such as aging populations, poor productivity growth and high debt levels mean historically low government bond yields are likely here to stay.

But after figures showed trade had subtracted 1.7 % from fourth - quarter gross domestic product (GDP) growth, this factor again seemed likely to prove a significant headwind, as January's trade deficit grew to its widest level since 2012.

Growth has been underpinned by a number of factors, including a high level of consumer confidence, a decline in the unemployment rate, favourable financial conditions and increases in wealth, fostered by rising housing prices.

Strong favorable demographic factors such as increasing disposable income levels and spending capabilities, rising consumer awareness and a hectic lifestyle of busy professionals are driving the growth of the packaging industry in Indonesia.

It offers a broad collection of nutrients that revitalize the human body on a cellular level, including vitamins, minerals, amino acids, enzymes, growth factors and other phytonutrients.

Although we have a theoretical explanation (putting more growth factors into an injured area), it is unclear what, if anything, is actually occurring on a more microscopic level.

Yes, inflation, past qualifying success, and fan growth all factor in, but ticket prices have clearly soared to obscene levels.

- These children also had an average of 8 percent higher blood levels of IGF - 1, or insulin - like growth factor, which promotes bone growth.

These studies have demonstrated higher levels of the growth factors that improve healing and lower levels of the growth factors that are thought to reduce healing rates.

They found that exercise may help cognition by increasing blood and oxygen to the brain, increasing levels of norepinephrine, and endorphins to decrease stress and improve mood, and increasing growth factors that help create new nerve cells and support synaptic plasticity.

Again, remember that these amounts are highly based on various factors such as growth rate, sex, and activity level.

Another reason not to fixate on a number on a growth chart is that your baby's well - being involves a variety of factors, including development, temperament, and activity level, not just growth.

However, the changes in climatic conditions arising from climate change could represent a far more important factor here: i.e. temperatures that increasingly exceed the optimum level for plant growth, like those experienced this summer, shifts in the vegetation periods, and more frequent droughts.

This happens because the loss of blood flow in a vessel causes the local oxygen level to drop, which stimulates local production of vascular endothelial growth factor, or VEGF, a protein which in most tissues causes the growth of new blood vessels to repair damage.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

Two months after therapy, tissue analysis showed less scarring and higher levels of regenerative agents such as fibroblast growth factor — which accelerate healing — in rats treated with SIS plus stem cells compared with those treated with SIS alone.

But successful approaches are converging on a few key areas: calorie restriction; reducing levels of insulinlike growth factor 1 (IGF - 1), a protein; and preventing oxidative damage to the body's tissues.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

One of these, called CTGF or connective tissue growth factor, was intriguing because its levels rose in the supporting cells, or glia, that formed the bridge in the first two weeks following injury.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.

According to the report, high levels of sFlt1 could result in a compromised vascular system by reducing the available amount of these growth factors in the blood supply.

Hippocampus: Involved in memory and navigation, the hippocampi of germ - free mice have reduced levels of molecules that sense serotonin and the growth factor BDNF.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

The team also performed a biochemical screen to identify molecules expressed in scar tissue and discovered relatively high levels of factors that support axon growth.

Among the suspected reasons: chronic low - level inflammation, too much insulin, excess hormones and growth factors released by fat tissue, and metabolic abnormalities.

«It's abdominal obesity, and even more specifically, levels of a protein called fibroblast growth factor - 2 that may be a better indicator of the risk of cells becoming cancerous.»

Studying mouse models of glaucoma, Ban, Apte and their colleagues identified a molecule in the eye called growth differentiation factor 15 (GDF15), noting that the levels of the molecule increased as the animals aged and developed optic nerve damage.

Bovine growth hormone is also known to stimulate the production of insulinlike growth factor 1 (IGF1) by the liver; some studies have shown that high levels of IGF1 in the bloodstream may heighten the risk of prostate and breast cancers as well as a woman's chance of conceiving twins.

High Serum Vascular Endothelial Growth Factor (VEGF) Level Is An Adverse Prognostic Factor In High Risk Diffuse Large B - Cell Lymphoma (DLBCL) Patients Treated with Dose - Dense Chemoimmunotherapy and Systemic CNS Prophylaxis.

This happens because the loss of blood flow in a blood vessel causes the local oxygen level to drop, which stimulates local production of vascular endothelial growth factor, or VEGF, a protein that in most tissues causes the growth of new blood vessels to repair damage.

However, future island vulnerability is a complex and arguably island - specific issue and will be influenced by various interacting factors that include the rate of reef growth, the rate of sea - level rise, reef evolutionary stage and thus accommodation space, island geomorphology, and the contemporary relationship between islands and their surrounding process and sedimentary regimes (Perry et al., 2011).

They also identified targets for potential therapies: bolstering levels of either a particular chaperone or a growth factor in brain cells can protect against the toxic effects of misfolded proteins.

«In a young, healthy individual, hypoxia — low oxygen levels — triggers the body to make factors that help coordinate the growth of new blood vessels but this process doesn't work as well as we age,» says Gregg Semenza, M.D., Ph.D., professor of pediatrics and genetic medicine and director of the vascular biology program at the Johns Hopkins Institute for Cell Engineering.

Protein secretion does not always mirror mRNA levels and most workers in the field would adopt a more conservative profile of cytokine and growth factor production by MSC.

In mice with an altered level of the growth factor, there was no regression of the temporary blood vessels.

Cyclin D1 - levels varying throughout cell cycle, hence its expression in G1 phase increases in the cell that respond to enter a new cycle after receiving growth factor stimulation [8].

(6) Moreover, subcutaneous adipose of prematurely - aged transgenic mice exhibited high levels of staining for the senescence marker senescence - associated - β - galactosidase (SAβ - gal) and expressed high levels of several established markers of senescence, including p21, p19, interleukin - 6, (insulin - like growth factor binding protein - 2 (Igfbp2), and Pai - 1; primary BubR1H / H; INK - ATTAC mouse embryonic fibroblasts forced artificially into senescence by oncogenic Ras or serial passage exhibited a subpopulation that was both GFP + and stained positively SAβ - gal.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.