Sentences with phrase «growth factor signals»

His group focuses on exploring the mechanisms by which growth factor signals in the stem cell environment modulate the pluripotent stem cell's functional properties.

In addition to its known roles in cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammation.

«Obesity - associated metabolic perturbations are emerging as major drivers of obesity - related cancer, including alterations in growth factor signaling, inflammation, and angiogenesis,» explained Dr. Hursting.

[4] Of note, anosmin may enhance fibroblast growth factor signaling through the fibroblast growth factor receptor 1.

Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.

She moved to Oxford in 2012 to work at the SGC, initially working in Alex Bullock's Growth Factor Signalling group to study E3 ubiquitin ligase complexes, and subsequently joining Stefan Knapp's kinase team to focus on kinase structural biology and inhibitor discovery.

Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins.

Abbreviations: AL3E, after L3 ecdysis; FoxO, Forkhead Box O; FRE, FoxO - Response Element; GBP, Growth - Blocking Peptide; GFP, green fluorescent protein; IIS, insulin / insulin - like growth factor signaling; ILP, insulin - like peptide; L3, third larval instar; pAKT, phosphorylated AKT; ppl, pumpless; qPCR, quantitative PCR; Rheb, Ras homolog enriched in brain ortholog; TOR, Target of Rapamycin

In addition, we found that GBPs stimulate ILP secretion from the insulin - producing cells, either directly or indirectly, thereby increasing insulin and insulin - like growth factor signaling activity throughout the body.

Not exact matches

It can be useful to divide it into two groups of factors: Growth factors are good indicators of a business's health and can help signal where it's headed.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

In contrast, Loeys - Dietz is traced to a genetic defect in the TGF — beta (transforming growth factor — beta) signaling pathway.

They began snipping off the tip of a growing tail at one stage and stapling it, with fine tungsten wire, to a later stage, to see if the growth factors in action during early tail growth could override the stopping signals.

Vibration helped tissue to form new blood vessels — a process called angiogenesis — and also led to increased expression of pro-healing growth factors and signaling molecules called chemokines, Weinheimer - Haus said.

It seemed so obvious that if fairly small changes in development, which adjusted the timing and concentrations of growth and signaling factors, could have led to the evolution of birds from nonavian dinosaurs, we could readjust those changes in development and get a dinosaur from a chick embryo.

It would also deliver antibiotics to control infection and signal molecules known as growth factors to accelerate skin regeneration.

A study published in the journal PLOS ONE reports that the synthetic molecule JK - 31 blocks the signalling of a «growth factor» chemical that promotes the creation of networks of blood vessels to feed tumors.

Designed for use in spinal fusion surgery of the lower back, Infuse consists of a titanium cage that houses a collagen sponge soaked in bone morphogenetic protein (BMP), a growth factor that signals bone - forming cells to produce new tissue.

Suppression of signaling by insulin and the related hormone insulin - like growth factor - 1 (IGF - 1) extends life span in many species.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

About ten years ago, research results showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

SU101 targets the signal transduction activated by a messenger called platelet - derived growth factor, which controls the genes involved in tissue formation and wound healing.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

Gerontologists are very familiar with the insulin / IGF (insulin - like growth factor) signalling pathway.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

The team's findings paint a clear picture: in alert mode, the stem cells emit signaling substances, which in turn induce tissue cells to release the connective tissue growth factor (CTGF) messenger.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

Dr. Doyle then trained as a postdoctoral scholar at Stanford University under the mentorship of Dr. Marion Buckwalter, researching the role of transforming growth factor (TGF)- beta signaling after stroke and developing a model of poststroke dementia.

That will require fully characterizing the protein and figuring out how DAZAP1 senses external signals like nutrients or growth factors that regulate its properties.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

In pancreatic cancer cells, low doses of aspirin stopped the platelets from releasing growth factor and hampered the signaling of the oncoproteins that cause cancer to survive and spread.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

They also found that when under stress from chemotherapy, megakaryocytes signaled fibroblast growth factor 1 (FGF1), to stimulate the proliferation of hematopoietic stem cells.

The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that functions in an insulin / insulin - like growth factor (IGF) signaling pathway.

In the course of their research, they found that the protein transforming growth factor B1 (TGF - B1), contained in megakaryocytes, signaled quiescence of hematopoietic stem cells.

The drug Gefitinib is used to treat breast, lung, and other cancers by inhibiting epidermal growth factor receptor (EGFR) signaling, but it has only a limited effect on prostate cancer.

Alice Shaw recalls a signal moment in 2004 — just as she was finishing her oncology fellowship at MIT — when scientists discovered that mutations in a gene for epidermal growth factor receptor (EGFR) were the culprits in about 10 to 15 percent of lung cancer patients.

«We have already observed that gene egr - 4 is regulated by the epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway during anterior regeneration.

Bevacizumab, a monoclonal antibody, is an angiogenesis inhibitor that targets a chemical signal, vascular endothelial growth factor A (VEGF - A).

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

In worms, mice and flies, for instance, researchers have radically extended lifespan by suppressing genes involved in growth - factor signalling, or by restricting food.

The authors also noticed that signaling from the growth factor BMP (bone morphogenetic protein) was highly active in the SATB2 - expressing region of the gut tube.

Now Grove and a colleague, reporting in todays Science, have found that Fibroblast Growth Factor 8 (FGF8), whose absence prevents limbs from growing normally, acts as a signal telling the neocortex which way is front.

Decorin is a protein that is part of connective tissue like bone, but that also plays a signaling role, interacting with growth factors to slow the rate that cells divide and multiply, unless turned off by too much p53.

The growth factor VEGFA functions as a signalling molecule, regulating the protein complexes in the blood vessel walls.

4 The downstream signaling pathways of some growth factor receptors was also intact because many of the cell lines exhibited proliferative responses to certain of the known endothelial cell mitogens.

However, contrary to other studies of astrocyte de-differentiation [3, 4], epidermal growth factor (EGF)- mediated signaling had no role in astrocyte to NSC conversion.

Transforming growth factor β / Smad3 signaling regulates IRF - 7 function and transcriptional activation of the β interferon promoter.