Sentences with phrase «growth of cells with»

These new findings reveal that long, functional telomeres can sense chromosomal imbalances and suppress the proliferation and growth of cells with aneuploidy.

Not exact matches

To read his blog is to watch the growth of a human being: You see Ev nearly lose his company, bring it back from the dead, strike it big, struggle with the tech support for his new cell phone, and get married.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Some reports, such as the Open Philanthropy Project's Animal Product Alternatives report and Van der Weele & Tramper (2014) suggest it is unlikely that cultured meats will become cost - competitive with conventional meat.98, 99 One important contributing factor in this conclusion, which is cited in these reports, is the minimum costs of the growth medium necessary for culturing the desired cells.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

«We die daily»: so it is often said, not only with reference to the death of our bodily cells and their replacement by other cells every few years, but also in respect to our possible human growth.

We anticipate some sort of growth toward increased complexity: increasingly larger organic macromolecules, then the convergence of many macromolecules to constitute a simple living system, either as a cell with its protective wall and vital nucleus or as some functional analogue, then the convergence of many cells to form larger organisms.

Heretofore, this earth has witnessed the emergence of single - celled living organisms, the growth of multicelled plant organisms, the advent of animals with centralized nervous systems making self - directed activity possible, and the flowering of humanity with its far - flung culture.

Also, mushrooms are a great antioxidant and is filled with vitamin D, which helps inhibit the growth of cancer cells.

This is a quote that my nutrition teacher shared with the class and it helps to explain what I am saying: «The cause of nutrition and growth resides not in the organism as a whole but in the separate elementary parts — the cells.»

They found that epigallocatechin gallate, or EGCg, which is found in all tea, inhibits the activity of tNOX, an overactive enzyme that interferes with a cell's divide - and - rest cycle, and can facilitate uninterrupted growth of cancerous cells when combined with other factors.

Mogroside V has been found in research to have the ability to inhibit tumor growth in pancreatic cancer by interfering with the rapid dividing of cancer cells, preventing angiogenesis (blood flow to the tumor), and even promoting cancer cell death (10).

As well as containing vitamins and minerals its abundant with polyphenol antioxidants which help protect against cancer, one polyphenol in particular can slow or halt the growth of cancer cells!

Also functions as a hormone with roles in immune system health, insulin production, and regulation of cell growth.

In the new study, the scientists expressed surprise that the early abnormal growth of brain cells they observed in the fish embryo specifically affected male hormones, potentially indicating why more boys than girls are diagnosed with certain neurodevelopmental disorders such as autism.

Contributes to cell growth & regeneration of collagen when taken with iron and copper.

The phase 3 study, published online in The Lancet, is the latest to show the effectiveness of everolimus in slowing the cell growth that is overactive in patients with TSC.

«While environmental enrichment didn't seem to significantly influence the number of neurons [that were damaged],» explains Tsai, «it does induce the growth of dendrites and high numbers of synapses,» both of which are neuronal structures that underlie how brain cells communicate with one another.

A recent American Journal of Botany paper explains that conventional trees experience a secondary growth phase — replacing functional tissues with younger cells — but palm trees do not.

The cells, which lined the pores of the scaffold, were regularly fed with streams of nutrients, growth factors and oxygen in a bioreactor.

The mice were also injected with a dye that could illuminate the footprints of new nerve cell growth in the brain.

In the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammation.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

The result fit with prior research indicating that accelerated growth of new brain cells in the dentate gyrus, in a process called neurogenesis, is necessary for antidepressants to cure rats of their depression.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

The current paper shows that treating with retinoids simultaneously with anti-estrogen therapies may pull cofactors for progesterone receptors away from their posts, disallowing their ability to open DNA at the point of CK5 and keeping the growth of dangerous CK5 + cells in check.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

A blood cancer characterized by the rapid growth of abnormal white blood cells, AML is typically treated with chemotherapy, in some cases followed by a stem cell transplant.

To find it, the scientists injected the eight tumor - bearing mice with high levels of labeled glutamine and glucose, another metabolic compound commonly linked to the growth of pancreatic cancer cells.

In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease spread.

«We showed that the coupling of cell wall growth to mechanical strain is quantitatively consistent with how bacteria recovered their shape after being deformed in experiments.»

And she had to work with bone cells to see how they would react to contact with the material and to determine what level of microvibration would best stimulate cell growth.

To do so they focused on keratinocytes, a specific type of skin cells with a key role in psoriasis because of their abnormal growth and ability to produce large amounts of inflammation promoting factors.

Researchers in the Rice lab of chemist and bioengineer Jeffrey Hartgerink had just such an experience with the hydrogels they developed as a synthetic scaffold to deliver drugs and encourage the growth of cells and blood vessels for new tissue.

Isoflavones have been shown to slow the growth of breast cancer cells in laboratory studies, and epidemiological analyses in East Asian women with breast cancer found links between higher isoflavone intake and reduced mortality.

Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis of human basal - like breast cancer cells.

With these in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer cell growth, metastasis and ability of the tumors to recur after radiation therapy.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Women with the KRAS - variant are also more susceptible to triple - negative breast cancer, tumors whose growth is not fueled by the hormones estrogen and progesterone, or by the presence of a particular genetic mutation known as HER2, which promotes cancer cell growth.

New findings published in the Proceedings of the National Academy of Sciences showed in lab studies that supplementing an epigenetic cancer drug called decitabine with vitamin C enhanced the drug's ability to impede cancer cell growth and trigger cellular self - destruction in cancer cell lines.

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

Yanhai Yin, a professor of genetics, development and cell biology and a Plant Sciences Institute Faculty Scholar, said the biological processes that oversee plant growth and drought response often clash with one another.

Two months after therapy, tissue analysis showed less scarring and higher levels of regenerative agents such as fibroblast growth factor — which accelerate healing — in rats treated with SIS plus stem cells compared with those treated with SIS alone.

In this study, the researchers noted that conventional approaches to modifying organisms to consume novel nutrients constitutively (i.e. with no «off switch») can lead to inefficiencies when the nutrient metabolic pathways are not linked to downstream pathways for stress - responses, cell growth and other functions important for the health of the organism.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

The study builds on previous findings suggesting that AIM2 limits cancer cell growth in colon cancer cell lines, Wilson said, as well as on a clinical report of poor prognosis in colon cancer patients with low or missing AIM2 levels.

The MIT team estimated that if there were a way to detect when patients» white cell counts went below the threshold level, so they could be treated with prophylactic antibiotics and drugs that promote white blood cell growth, about half of the 110,000 infections that occur in chemotherapy patients in the United States every year could be prevented.

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.