Sentences with phrase «growth of endothelial cells»

Therefore, we studied the effects of kahweol on the growth of endothelial cells.

VEGF normally promotes the growth of endothelial cells, which in turn helps build new blood vessels in tumors.

Not exact matches

So Daniel Anderson at the Massachusetts Institute of Technology exposed human bone marrow stem cells to biodegradable nanoparticles carrying the human gene for vascular endothelial growth factor (VEGF), which attracts blood vessels to injury sites.

And they incorporated into the gel a protein known as vascular endothelial growth factor (VEGF), which encourages the growth of blood vessels into the transplanted cells.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

By blocking these in lung endothelial cells, the researchers were able to slow lung tumor growth in mice and also reduce the spread of metastatic tumors.

The scientists in Augustin's laboratory consequently pursued preclinical tumor therapy experiments, which were aimed at not just blocking angiogenesis, but to also suppress the production of tumor - promoting growth factors in endothelial cells.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

Yet, more recent discoveries suggest a much more active role of endothelial cells during tumor growth than has been anticipated so far.

These analyses showed that Angiopoietin - 2 is not just affecting angiogenesis, but controls at the same time the production of tumor promoting growth factors in endothelial cells.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

During the creation of new blood vessels, the vascular endothelial growth factor (VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels.

Similar to cells growing at 33 °C, endothelial cells plated in the 37 °C environment also engaged in cell division during the first 24 h. However, during the next 72 h, the growth of most endothelial cells in 37 °C conditions dropped to 50 % of that of their counterparts growing at 33 °C (data not shown).

4 The downstream signaling pathways of some growth factor receptors was also intact because many of the cell lines exhibited proliferative responses to certain of the known endothelial cell mitogens.

Initial imaging analysis of fluorescently labelled human iPSC - derived hepatic endoderm cells, umbilical cord - derived endothelial cells (HUVECs), and mesenchymal stem cells (MSCs) co-cultured in a solidified matrix gel to promote 3D growth found that the different cells collectively and automatically «condensed» into a multicellular central unit.

Researchers from the laboratories of Hiroshi Y. Yoshikawa and Hideki Taniguchi had previously demonstrated the in vitro formation of a 3D transplantable liver «organ bud» from human induced pluripotent stem cells (iPSCs) co-cultured with mesenchymal and endothelial progenitors, and allows for the growth of a small vascularized and functional organ [1 - 3].

Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second - line therapy of small cell lung cancer (NCI # 7097).

Other research has shown that oxygen - deprived cells in the retina produce a type of protein called vascular endothelial growth factor (VEGF), which triggers the growth of new blood vessels in the retina.

Vascular endothelial growth factor (VEGF) expressed by neural progenitor cells (NPCs)(cyan) stimulates the growth of blood vessels (red) in the mouse embryonic hindbrain, and provides regulatory factors to promote the self - renewal of neural progenitors.

In fact, several of the best characterized anti-angiogenic compounds were initially detected and selected for their capability to interfere with endothelial cell growth.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

The researchers found that, when stimulated by insulin, diabetic fibroblasts produced less of the VEGF (vascular endothelial growth factor) signaling protein, a key player in boosting the growth of blood vessel cells, than normal fibroblasts did.

This data should be useful for determining the growth potential and characteristics of human corneal endothelial cells in the development of artificial corneas.

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

At the same time, the protein Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem Cell Factor (SCF) stimulates your native inactive stem cells to become activated and assist in the repair of the damaged tissue.

Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage cells and in membranes that line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular endothelial growth factor, which promotes excessive growth of blood vessels in inflamed joints.

These measures include enhancing the flow of urine by achieving and maintaining proper hydration, promoting a pH that will inhibit the growth of the organism, and preventing bacterial adherence to the endothelial cells of the bladder.

/ consuming Animal proteins cause numerous proteins as it is not designed for us / may be designed to grow that animal at a rate much faster than we are designed for / and also feeds the growth of Cancer cells / damages the Endothelial cells / ala Dr. Esselstyn and others.

One of these growth factors is vascular endothelial growth factor - A or VEGF, which acts by binding specific receptors on the hemangiosarcoma cells.