Teams from CNRS, the Université de Strasbourg and Inserm, led by Daniel Riveline [1], Jean - Marie Lehn [2] and Marie - France Carlier [3], have synthesized molecules capable of causing rapid
growth of actin networks, one of the components of the cytoskeleton.
Not exact matches
In addition, they have identified the
growth mechanism
of the
actin network by comparative in vivo and in vitro studies in order to ensure the validity
of the process.
Derived from supramolecular chemistry [4], the new compounds synthesized by the researchers have original properties: within several minutes, they bring about the
growth of lamellar networks
of actin filaments.
Polarized
growth in the absence
of F -
actin in Saccharomyces cerevisiae exiting quiescence.
Much
of this dynamic happens in close proximity to the plasma membrane due to the fact that
actin assembly factors are membrane - bound, and thus
actin filaments are generally oriented such that their
growth occurs against or near the membrane.
Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator
of actin cytoskeleton dynamics (i.e. the inner structural support
of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel
growth), inflammation, and fibrosis (thickening and scarring
of tissue) associated with choroidal neovascularization (CNV) in wet AMD.
We already have evidence that endocytosis is involved in the spatial restriction
of motogenic signals, leading to localised
actin remodelling in response to
growth factor stimulation (14).